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    STI1 Hsp90 cochaperone STI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854192, updated on 9-Jun-2019

    Summary

    Gene symbol
    STI1
    Gene description
    Hsp90 cochaperone STI1
    Primary source
    SGD:S000005553
    Locus tag
    YOR027W
    Gene type
    protein coding
    RNA name
    Hsp90 cochaperone STI1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

    Genomic context

    See STI1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (381053..382822)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene NAD-dependent histone deacetylase HST3 Neighboring gene Bub3p Neighboring gene Cin5p Neighboring gene hypothetical protein

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the STI1 gene: The STI1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    Hsp90 cochaperone STI1
    NP_014670.1
    • Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      381053..382822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183446.1NP_014670.1  TPA: Hsp90 cochaperone STI1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P15705
      Conserved Domains (4) summary
      smart00727
      Location:537576
      STI1; Heat shock chaperonin-binding motif
      sd00006
      Location:533
      TPR; TPR repeat [structural motif]
      cl26002
      Location:5490
      TPR_11; TPR repeat
      cl26005
      Location:396549
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
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