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    Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25604, updated on 13-Mar-2018
    Official Symbol
    Pcmt1provided by RGD
    Official Full Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase 1provided by RGD
    Primary source
    RGD:3268
    See related
    Ensembl:ENSRNOG00000014330
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PCM
    Summary
    catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 550.2), Heart (RPKM 539.4) and 9 other tissues See more
    Orthologs
    See Pcmt1 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1734863..1767759, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (3432543..3464945, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348623 Neighboring gene ribosomal protein L23a pseudogene Neighboring gene LDL receptor related protein 11 Neighboring gene nucleoporin 43 Neighboring gene large tumor suppressor kinase 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC95039

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    S-adenosylhomocysteine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    S-adenosylmethionine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein methylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    protein-L-isoaspartate(D-aspartate) O-methyltransferase
    Names
    L-isoaspartyl protein carboxyl methyltransferase
    PIMT
    protein L-isoaspartyl/D-aspartyl methyltransferase
    protein-beta-aspartate methyltransferase
    NP_037205.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013073.3NP_037205.2  protein-L-isoaspartate(D-aspartate) O-methyltransferase

      See identical proteins and their annotated locations for NP_037205.2

      Status: PROVISIONAL

      Source sequence(s)
      BC088417
      UniProtKB/Swiss-Prot
      P22062
      Related
      ENSRNOP00000019623.7, ENSRNOT00000019623.7
      Conserved Domains (2) summary
      pfam01135
      Location:8216
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:13220
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      1734863..1767759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      659884..692976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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