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    C6 complement C6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24237, updated on 5-Aug-2018

    Summary

    Official Symbol
    C6provided by RGD
    Official Full Name
    complement C6provided by RGD
    Primary source
    RGD:2238
    See related
    Ensembl:ENSRNOG00000024115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    component of the complement cascade for immune response; may be a component of the membrane attack complex [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 978.1) and Lung (RPKM 85.9) See more
    Orthologs

    Genomic context

    Location:
    2q16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54460333..54533801)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (73494910..73562334)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349953 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 3 Neighboring gene septin-7-like Neighboring gene maestro heat-like repeat-containing protein family member 2B-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    complement activation IEA
    Inferred from Electronic Annotation
    more info
     
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cytolysis IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of activation of membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane attack complex IEA
    Inferred from Electronic Annotation
    more info
     
    membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    complement component C6
    Names
    complement component 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176074.3NP_788263.1  complement component C6 precursor

      See identical proteins and their annotated locations for NP_788263.1

      Status: PROVISIONAL

      Source sequence(s)
      AY230250
      UniProtKB/Swiss-Prot
      Q811M5
      Related
      ENSRNOP00000029891.4, ENSRNOT00000033112.4
      Conserved Domains (6) summary
      cd00033
      Location:644700
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:704756
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00057
      Location:862934
      FIMAC; factor I membrane attack complex
      smart00209
      Location:568612
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:142173
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01823
      Location:292514
      MACPF; MAC/Perforin domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      54460333..54533801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760750.2XP_008758972.1  complement component C6 isoform X2

      Conserved Domains (6) summary
      cd00033
      Location:644688
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:704756
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00057
      Location:862934
      FIMAC; factor I membrane attack complex
      smart00209
      Location:568612
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:142173
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01823
      Location:292514
      MACPF; MAC/Perforin domain
    2. XM_008760747.2XP_008758969.1  complement component C6 isoform X1

      See identical proteins and their annotated locations for XP_008758969.1

      Conserved Domains (5) summary
      cd00033
      Location:464508
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:524576
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00057
      Location:682754
      FIMAC; factor I membrane attack complex
      smart00209
      Location:388432
      TSP1; Thrombospondin type 1 repeats
      pfam01823
      Location:112334
      MACPF; MAC/Perforin domain
    3. XM_008760749.2XP_008758971.1  complement component C6 isoform X1

      See identical proteins and their annotated locations for XP_008758971.1

      Conserved Domains (5) summary
      cd00033
      Location:464508
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:524576
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00057
      Location:682754
      FIMAC; factor I membrane attack complex
      smart00209
      Location:388432
      TSP1; Thrombospondin type 1 repeats
      pfam01823
      Location:112334
      MACPF; MAC/Perforin domain

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      49510682..49574053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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