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    htl heartless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42160, updated on 19-Mar-2019

    Summary

    Official Symbol
    htlprovided by FlyBase
    Official Full Name
    heartlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010389
    Locus tag
    Dmel_CG7223
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7223; CT22273; CT39172; DFGF-R1; DFGF-R2; Dfr-1; DFR-1; Dfr1; DFR1; DFR1/DFGF-R2; Dmel\CG7223; DmHD-38; DPR3; dtk1; Dtk1; DTRK(FR1); EMS2; FGF-R2; FGFR; FGFR2; Fr1; FR1; HD-38; Htl; HTL/FGFR1; i100; i150; i79; j372; Tk1

    Genomic context

    See htl in Genome Data Viewer
    Location:
    90E2-90E2; 3-62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.18 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18045216..18052984, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13870938..13878706, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glycine-TCC 1-3 Neighboring gene stripe

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor-activated receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor ligand activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cardioblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    central nervous system development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-negative bacterium HMP PubMed 
    endodermal cell fate determination IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ensheathment of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell projection elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gonad development TAS
    Traceable Author Statement
    more info
    PubMed 
    gonadal mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heart development TAS
    Traceable Author Statement
    more info
    PubMed 
    larval visceral muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymph gland crystal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymph gland plasmatocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm migration involved in gastrulation TAS
    Traceable Author Statement
    more info
    PubMed 
    mesodermal cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesodermal cell fate determination IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesodermal cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pericardial nephrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pole cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of innate immune response HMP PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    salivary gland development TAS
    Traceable Author Statement
    more info
    PubMed 
    somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visceral muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    heartless
    Names
    CG7223-PA
    CG7223-PB
    CG7223-PC
    FGF receptor
    fibroblast growth factor receptor
    fibroblast growth factor receptor 1
    htl-PA
    htl-PB
    htl-PC
    NP_524394.2
    NP_732286.1
    NP_732287.1

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18045216..18052984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079670.3NP_524394.2  heartless, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524394.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07407
      Related
      FBpp0082970, FBtr0083548
      Conserved Domains (4) summary
      smart00221
      Location:416688
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:113191
      IG_like; Immunoglobulin like
      cl11960
      Location:112191
      Ig; Immunoglobulin domain
      cl21453
      Location:404692
      PKc_like; Protein Kinases, catalytic domain
    2. NM_169785.2NP_732287.1  heartless, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732287.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07407
      Related
      FBpp0082972, FBtr0083550
      Conserved Domains (4) summary
      smart00221
      Location:416688
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:113191
      IG_like; Immunoglobulin like
      cl11960
      Location:112191
      Ig; Immunoglobulin domain
      cl21453
      Location:404692
      PKc_like; Protein Kinases, catalytic domain
    3. NM_169784.2NP_732286.1  heartless, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07407
      Related
      FBpp0082971, FBtr0083549
      Conserved Domains (4) summary
      smart00221
      Location:416688
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:113191
      IG_like; Immunoglobulin like
      cl11960
      Location:112191
      Ig; Immunoglobulin domain
      cl21453
      Location:404692
      PKc_like; Protein Kinases, catalytic domain
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