Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    ADCY10 adenylate cyclase 10, soluble [ Homo sapiens (human) ]

    Gene ID: 55811, updated on 22-Apr-2017
    Official Symbol
    ADCY10provided by HGNC
    Official Full Name
    adenylate cyclase 10, solubleprovided by HGNC
    Primary source
    HGNC:HGNC:21285
    See related
    Ensembl:ENSG00000143199 MIM:605205; Vega:OTTHUMG00000034573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAC; HCA2; SACI; Sacy; hsAC; HEL-S-7a
    Summary
    The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
    Orthologs
    Location:
    1q24.2
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (167809080..167915556, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167778357..167883608, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transfer RNA-Pro (AGG) 2-1 Neighboring gene myelin protein zero like 1 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene microRNA 1255b-2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Circadian entrainment, organism-specific biosystem (from KEGG)
      Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian entrainment, conserved biosystem (from KEGG)
      Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Endothelin Pathways, organism-specific biosystem (from WikiPathways)
      Endothelin Pathways, organism-specific biosystemEndothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of i...
    • Hedgehog 'off' state, organism-specific biosystem (from REACTOME)
      Hedgehog 'off' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
    • Purine metabolism, organism-specific biosystem (from KEGG)
      Purine metabolism, organism-specific biosystem
      Purine metabolism
    • Purine metabolism, conserved biosystem (from KEGG)
      Purine metabolism, conserved biosystem
      Purine metabolism
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
      Signaling by Hedgehog, organism-specific biosystemHedgehog (Hh) is a secreted morphogen that regulates developmental processes in vertebrates including limb bud formation, neural tube patterning, cell growth and differentiation (reviewed in Hui and ...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    bicarbonate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular response to inorganic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    basal part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    adenylate cyclase type 10
    Names
    3',5'-cyclic AMP synthetase
    AH-related protein
    ATP pyrophosphate-lyase
    epididymis secretory sperm binding protein Li 7a
    germ cell soluble adenylyl cyclase
    testicular soluble adenylyl cyclase (SAC)
    NP_001161221.1
    NP_001284701.1
    NP_060887.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016139.1 RefSeqGene

      Range
      4990..109829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001167749.2NP_001161221.1  adenylate cyclase type 10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AF299350, AK302884, BC117366, DB063660
      Consensus CDS
      CCDS53426.1
      UniProtKB/Swiss-Prot
      Q96PN6
      Related
      ENSP00000441992.1, OTTHUMP00000274085, ENST00000545172.5, OTTHUMT00000471943
      Conserved Domains (1) summary
      cd07302
      Location:139308
      CHD; cyclase homology domain
    2. NM_001297772.1NP_001284701.1  adenylate cyclase type 10 isoform 3

      See identical proteins and their annotated locations for NP_001284701.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF299350, AF331033, AK302884, BC117366, DB063660
      Consensus CDS
      CCDS72977.1
      UniProtKB/Swiss-Prot
      Q96PN6
      Related
      ENSP00000356822.1, OTTHUMP00000032526, ENST00000367848.1, OTTHUMT00000083664
      Conserved Domains (2) summary
      cd07302
      Location:200369
      CHD; cyclase homology domain
      cl11967
      Location:6122
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    3. NM_018417.5NP_060887.2  adenylate cyclase type 10 isoform 1

      See identical proteins and their annotated locations for NP_060887.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF299350, AK302884, BC117366, DB063660
      Consensus CDS
      CCDS1265.1
      UniProtKB/Swiss-Prot
      Q96PN6
      UniProtKB/TrEMBL
      A0A0K0K1J8
      Related
      ENSP00000356825.4, OTTHUMP00000032525, ENST00000367851.8, OTTHUMT00000083663
      Conserved Domains (2) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      167809080..167915556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509762.2XP_011508064.1  adenylate cyclase type 10 isoform X2

      Conserved Domains (3) summary
      cd07302
      Location:244413
      CHD; cyclase homology domain
      COG2114
      Location:42130
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
      cl11967
      Location:43142
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    2. XM_011509763.2XP_011508065.1  adenylate cyclase type 10 isoform X3

      Conserved Domains (2) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    3. XM_006711449.3XP_006711512.1  adenylate cyclase type 10 isoform X4

      Conserved Domains (2) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    4. XM_011509760.2XP_011508062.1  adenylate cyclase type 10 isoform X1

      See identical proteins and their annotated locations for XP_011508062.1

      UniProtKB/Swiss-Prot
      Q96PN6
      UniProtKB/TrEMBL
      A0A0K0K1J8
      Conserved Domains (2) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    5. XM_005245330.4XP_005245387.1  adenylate cyclase type 10 isoform X6

      Conserved Domains (3) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
      pfam13191
      Location:485669
      AAA_16; AAA ATPase domain
    6. XM_017001778.1XP_016857267.1  adenylate cyclase type 10 isoform X5

    7. XM_011509766.2XP_011508068.1  adenylate cyclase type 10 isoform X7

      Conserved Domains (3) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
      pfam13191
      Location:485669
      AAA_16; AAA ATPase domain

    RNA

    1. XR_921889.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      169200865..169305675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center