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    PTPRF protein tyrosine phosphatase receptor type F [ Homo sapiens (human) ]

    Gene ID: 5792, updated on 8-Oct-2019

    Summary

    Official Symbol
    PTPRFprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Fprovided by HGNC
    Primary source
    HGNC:HGNC:9670
    See related
    Ensembl:ENSG00000142949 MIM:179590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAR; BNAH2
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 56.2), skin (RPKM 52.7) and 21 other tissues See more
    Orthologs

    Genomic context

    See PTPRF in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (43522238..43623672)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43991708..44089343)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene Sharpr-MPRA regulatory region 4928 Neighboring gene hydroxypyruvate isomerase (putative) Neighboring gene lysine demethylase 4A Neighboring gene uncharacterized LOC101929592 Neighboring gene KDM4A antisense RNA 1 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Breasts and/or nipples, aplasia or hypoplasia of, 2
    MedGen: C4014918 OMIM: 616001 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
    NHGRI GWA Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRF PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
      Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...
    • SALM protein interactions at the synapses, organism-specific biosystem (from REACTOME)
      SALM protein interactions at the synapses, organism-specific biosystemRecruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD9...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ43335, FLJ45062, FLJ45567

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chondroitin sulfate proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic membrane adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic membrane adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine phosphatase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase F
    Names
    LCA-homolog
    leukocyte antigen-related (LAR) PTP receptor
    leukocyte antigen-related tyrosine phosphatase
    leukocyte common antigen related
    protein tyrosine phosphatase, receptor type, F polypeptide
    receptor-linked protein-tyrosine phosphatase LAR
    NP_001316066.1
    NP_001316067.1
    NP_001316068.1
    NP_001316069.1
    NP_002831.2
    NP_569707.2
    XP_005271136.1
    XP_005271137.1
    XP_005271138.1
    XP_005271139.1
    XP_006710858.1
    XP_006710859.1
    XP_006710860.1
    XP_006710861.1
    XP_006710862.1
    XP_006710863.1
    XP_006710864.1
    XP_011540173.1
    XP_011540174.1
    XP_011540175.1
    XP_016857431.1
    XP_016857432.1
    XP_016857433.1
    XP_016857434.1
    XP_016857435.1
    XP_016857438.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047072.1 RefSeqGene

      Range
      13646..106429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001329137.1NP_001316066.1  receptor-type tyrosine-protein phosphatase F isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC092815, AL583862, BU624266, DA339772
    2. NM_001329138.1NP_001316067.1  receptor-type tyrosine-protein phosphatase F isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC092815, AL583862, BU624266, DA339772
    3. NM_001329139.1NP_001316068.1  receptor-type tyrosine-protein phosphatase F isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC092815, AL583862, BU624266
    4. NM_001329140.1NP_001316069.1  receptor-type tyrosine-protein phosphatase F isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AB621807, AC092815, AL583862, BU624266
      UniProtKB/TrEMBL
      G1UI20
    5. NM_002840.5NP_002831.2  receptor-type tyrosine-protein phosphatase F isoform 1 precursor

      See identical proteins and their annotated locations for NP_002831.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC092815, BC048768, BU624266, Y00815
      Consensus CDS
      CCDS489.2
      UniProtKB/Swiss-Prot
      P10586
      UniProtKB/TrEMBL
      G1UI20
      Related
      ENSP00000353030.4, ENST00000359947.9
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13511606
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13771606
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609696
      fn3; Fibronectin type III domain
    6. NM_130440.3NP_569707.2  receptor-type tyrosine-protein phosphatase F isoform 2 precursor

      See identical proteins and their annotated locations for NP_569707.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB621807, AC092815, BC048768, BU624266, Y00815
      Consensus CDS
      CCDS490.2
      UniProtKB/Swiss-Prot
      P10586
      UniProtKB/TrEMBL
      G1UI20
      Related
      ENSP00000398822.1, ENST00000438120.5
      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13421597
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13681597
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609696
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      43522238..43623672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541873.2XP_011540175.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_011540175.1

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13661621
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13921621
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    2. XM_011541871.3XP_011540173.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_011540173.1

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13661621
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13921621
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    3. XM_011541872.3XP_011540174.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_011540174.1

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13661621
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13921621
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    4. XM_006710795.3XP_006710858.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_006710858.1

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13661621
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13921621
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    5. XM_017001949.1XP_016857438.1  receptor-type tyrosine-protein phosphatase F isoform X16

    6. XM_005271079.3XP_005271136.1  receptor-type tyrosine-protein phosphatase F isoform X1

      See identical proteins and their annotated locations for XP_005271136.1

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13661621
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13921621
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    7. XM_006710798.3XP_006710861.1  receptor-type tyrosine-protein phosphatase F isoform X7

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13461601
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13721601
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    8. XM_017001944.1XP_016857433.1  receptor-type tyrosine-protein phosphatase F isoform X11

    9. XM_005271082.3XP_005271139.1  receptor-type tyrosine-protein phosphatase F isoform X13

      Conserved Domains (8) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:12401495
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:12661495
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
    10. XM_006710801.3XP_006710864.1  receptor-type tyrosine-protein phosphatase F isoform X14

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:11731428
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:11991428
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    11. XM_017001946.1XP_016857435.1  receptor-type tyrosine-protein phosphatase F isoform X15

    12. XM_006710797.3XP_006710860.1  receptor-type tyrosine-protein phosphatase F isoform X5

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13551610
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13811610
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    13. XM_006710796.3XP_006710859.1  receptor-type tyrosine-protein phosphatase F isoform X3

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13571612
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13831612
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:613700
      fn3; Fibronectin type III domain
    14. XM_006710799.3XP_006710862.1  receptor-type tyrosine-protein phosphatase F isoform X8

      Conserved Domains (8) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:12641519
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:12901519
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
    15. XM_006710800.3XP_006710863.1  receptor-type tyrosine-protein phosphatase F isoform X9

      Conserved Domains (8) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:12551510
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:12811510
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
    16. XM_005271080.3XP_005271137.1  receptor-type tyrosine-protein phosphatase F isoform X2

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13621617
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13881617
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609696
      fn3; Fibronectin type III domain
    17. XM_005271081.3XP_005271138.1  receptor-type tyrosine-protein phosphatase F isoform X6

      Conserved Domains (9) summary
      cd00096
      Location:50121
      Ig; Immunoglobulin domain
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:13531608
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13791608
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609696
      fn3; Fibronectin type III domain
    18. XM_017001943.1XP_016857432.1  receptor-type tyrosine-protein phosphatase F isoform X10

    19. XM_017001945.1XP_016857434.1  receptor-type tyrosine-protein phosphatase F isoform X12

    20. XM_017001942.2XP_016857431.1  receptor-type tyrosine-protein phosphatase F isoform X4

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