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    PRDM14 PR/SET domain 14 [ Homo sapiens (human) ]

    Gene ID: 63978, updated on 11-Apr-2024

    Summary

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    Official Symbol
    PRDM14provided by HGNC
    Official Full Name
    PR/SET domain 14provided by HGNC
    Primary source
    HGNC:HGNC:14001
    See related
    Ensembl:ENSG00000147596 MIM:611781; AllianceGenome:HGNC:14001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PFM11
    Summary
    This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (70051651..70071252, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (70481509..70501107, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (70963886..70983487, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:70858967-70859547 Neighboring gene syndecan binding protein pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:70869603-70869811 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:70887580-70888508 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:70889439-70890367 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:70891108-70891790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:70907101-70907667 Neighboring gene SUMO2 pseudogene 20 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:70919765-70920266 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:70923018-70923212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27504 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:70973261-70973851 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:70982981-70983710 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:70983711-70984440 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:70986286-70987132 Neighboring gene RNA, U1 small nuclear 101, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5072 Neighboring gene H2A.Z histone pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PRDM14 mediates chemosensitivity and glycolysis in drug‑resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells. He S, et al. Mol Med Rep, 2021 Feb. PMID 33355367, Free PMC Article
    2. A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons. Sybirna A, et al. Nat Commun, 2020 Mar 9. PMID 32152282, Free PMC Article
    3. PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer. Igarashi H, et al. Clin Transl Oncol, 2020 Jul. PMID 31741141
    4. Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14. Tracey LJ, et al. Trends Genet, 2019 Jul. PMID 31130394, Free PMC Article
    5. Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer. Taniguchi H, et al. Methods Mol Biol, 2019. PMID 31099008

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.
      Title: YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.
    2. LncRNA DNAJC3-AS1 functions as oncogene in renal cell carcinoma via regulation of the miR-27a-3p/PRDM14 axis.
      Title: LncRNA DNAJC3-AS1 functions as oncogene in renal cell carcinoma via regulation of the miR-27a-3p/PRDM14 axis.
    3. PRDM14 mediates chemosensitivity and glycolysis in drugresistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells.
      Title: PRDM14 mediates chemosensitivity and glycolysis in drug‑resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells.
    4. PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer.
      Title: PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer.
    5. PRDM14 targets are not conserved between mouse and human, emphasising the divergent molecular mechanisms of primordial germ cell specification.
      Title: A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons.
    6. PRDM14 is implicated in cancer initiation.[review]
      Title: Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14.
    7. RNA interference of PRDM14, a gene expressed by breast cancer cells, reduced the size of tumors and lung metastases in nude mice
      Title: Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer.
    8. High PRDM14 expression is associated with Cancer Stemness resulting in lung metastasis in breast cancer.
      Title: PRDM14, a Zinc Finger Protein, Regulates Cancer Stemness.
    9. Data show that elevated PRDM14 in PGCLCs causes proliferation and differentiation defects in the germline.
      Title: PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation.
    10. Our results suggest that PRDM14 serves as an initial trigger for epigenetic changes and hyperdynamic plasticity in tumors via bivalent chromatin domains.
      Title: Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of PR domain containing 14 (PRDM14) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59730

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in germ-line stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inner cell mass cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PR domain zinc finger protein 14
    Names
    PR domain 14
    PR domain-containing 14
    PR domain-containing protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024504.4 → NP_078780.1  PR domain zinc finger protein 14

      See identical proteins and their annotated locations for NP_078780.1

      Status: REVIEWED

      Source sequence(s)
      AF319458, CX166395, CX788380
      Consensus CDS
      CCDS6206.1
      UniProtKB/Swiss-Prot
      Q86UX9, Q9GZV8
      UniProtKB/TrEMBL
      A0A023UFG1
      Related
      ENSP00000276594.2, ENST00000276594.3
      Conserved Domains (4) summary
      smart00317
      Location:266 → 371
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:460 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:463 → 483
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:548 → 565
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      70051651..70071252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      70481509..70501107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZV8.1 GenPept UniProtKB/Swiss-Prot:Q9GZV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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