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    LIG4 DNA ligase 4 [ Homo sapiens (human) ]

    Gene ID: 3981, updated on 19-Jun-2017
    Official Symbol
    LIG4provided by HGNC
    Official Full Name
    DNA ligase 4provided by HGNC
    Primary source
    HGNC:HGNC:6601
    See related
    Ensembl:ENSG00000174405 MIM:601837; Vega:OTTHUMG00000017328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIG4S
    Summary
    The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    13q33.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (108207442..108218368, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (108859790..108870716, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 155 member A Neighboring gene microRNA 1267 Neighboring gene uncharacterized LOC107984581 Neighboring gene FAM155A intronic transcript 1 Neighboring gene abhydrolase domain containing 13 Neighboring gene TNF superfamily member 13b Neighboring gene RNA, 5S ribosomal pseudogene 39

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Lig4 syndrome
    MedGen: C1847827 OMIM: 606593 GeneReviews: Not available
    Compare labs
    Multiple myeloma
    MedGen: C0026764 OMIM: 254500 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
    NHGRI GWA Catalog
    • 2-LTR circle formation, organism-specific biosystem (from REACTOME)
      2-LTR circle formation, organism-specific biosystemThe formation of 2-LTR circles requires the action of the cellular non-homologous DNA end-joining pathway. Specifically the cellular Ku, XRCC4 and ligase IV proteins are needed. Evidence for this i...
    • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Early Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Early Phase of HIV Life Cycle, organism-specific biosystemIn the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Integration of provirus, organism-specific biosystem (from REACTOME)
      Integration of provirus, organism-specific biosystemFor retroviral DNA to direct production of progeny virions it must become covalently integrated into the host cell chromosome (reviewed in Coffin et al. 1997; Hansen et al. 1998). Analyses of mutants...
    • Non-homologous end-joining, organism-specific biosystem (from KEGG)
      Non-homologous end-joining, organism-specific biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
    • Non-homologous end-joining, conserved biosystem (from KEGG)
      Non-homologous end-joining, conserved biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
    • Nonhomologous End-Joining (NHEJ), organism-specific biosystem (from REACTOME)
      Nonhomologous End-Joining (NHEJ), organism-specific biosystemThe nonhomologous end joining (NHEJ) pathway is initiated in response to the formation of DNA double-strand breaks (DSBs) induced by DNA-damaging agents, such as ionizing radiation. DNA DSBs are reco...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA ligase (ATP) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA ligase activity TAS
    Traceable Author Statement
    more info
     
    ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA ligation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA ligation involved in DNA recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA ligation involved in DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA ligation involved in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell differentiation in thymus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell receptor V(D)J recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    V(D)J recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chromosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-strand break repair via classical nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-strand break repair via nonhomologous end joining TAS
    Traceable Author Statement
    more info
     
    establishment of integrated proviral latency TAS
    Traceable Author Statement
    more info
     
    immunoglobulin V(D)J recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    isotype switching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleotide-excision repair, DNA gap filling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pro-B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to gamma radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    single strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somatic stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    DNA ligase IV complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA-dependent protein kinase-DNA ligase 4 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-dependent protein kinase-DNA ligase 4 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    nonhomologous end joining complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IC
    Inferred by Curator
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    DNA ligase 4
    Names
    DNA joinase
    DNA ligase IV
    DNA repair enzyme
    ligase IV, DNA, ATP-dependent
    polydeoxyribonucleotide synthase [ATP] 4
    polynucleotide ligase
    sealase
    NP_001091738.1
    NP_002303.2
    NP_996820.1
    XP_005254113.1
    XP_005254114.1
    XP_005254115.1
    XP_006720014.1
    XP_006720015.1
    XP_011519393.1
    XP_011519394.1
    XP_016876052.1
    XP_016876053.1
    XP_016876054.1
    XP_016876055.1
    XP_016876056.1
    XP_016876057.1
    XP_016876058.1
    XP_016876059.1
    XP_016876060.1
    XP_016876061.1
    XP_016876062.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007396.1 RefSeqGene

      Range
      2167..13093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_79

    mRNA and Protein(s)

    1. NM_001098268.1NP_001091738.1  DNA ligase 4 isoform 1

      See identical proteins and their annotated locations for NP_001091738.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-10 all encode the same isoform (1).
      Source sequence(s)
      BC037491, BX648833
      Consensus CDS
      CCDS9508.1
      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Related
      ENSP00000385955.1, OTTHUMP00000275089, ENST00000405925.2, OTTHUMT00000474727
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    2. NM_001330595.1NP_001317524.1  DNA ligase 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a dowstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK292419, BC037491, BX648833, DC372305
      Consensus CDS
      CCDS81779.1
      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A0C4DGV9, A8K8Q4
    3. NM_001352598.1NP_001339527.1  DNA ligase 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1-3 and 6-10, encodes isoform 1.
      Source sequence(s)
      AL157762
    4. NM_001352599.1NP_001339528.1  DNA ligase 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1-3, 5, and 7-10, encodes isoform 1.
      Source sequence(s)
      AL157762
    5. NM_001352600.1NP_001339529.1  DNA ligase 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1-3, 5, 6, and 8-10, encodes isoform 1.
      Source sequence(s)
      AL157762
    6. NM_001352601.1NP_001339530.1  DNA ligase 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1-3, 5-7, 9, and 10, encodes isoform 1.
      Source sequence(s)
      AL157762
    7. NM_001352602.1NP_001339531.1  DNA ligase 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1-3, 5-8, and 10, encodes isoform 1.
      Source sequence(s)
      AL157762
    8. NM_001352603.1NP_001339532.1  DNA ligase 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1-3 and 5-9, encodes isoform 1.
      Source sequence(s)
      AL157762
    9. NM_001352604.1NP_001339533.1  DNA ligase 4 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) encodes the longest isoform (3).
      Source sequence(s)
      AL157762
    10. NM_002312.3NP_002303.2  DNA ligase 4 isoform 1

      See identical proteins and their annotated locations for NP_002303.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 3, and 5-10, encodes isoform 1.
      Source sequence(s)
      AI809944, BC037491, CD102896, X83441
      Consensus CDS
      CCDS9508.1
      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Related
      ENSP00000349393.3, ENST00000356922.5
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    11. NM_206937.1NP_996820.1  DNA ligase 4 isoform 1

      See identical proteins and their annotated locations for NP_996820.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-10 all encode the same isoform (1).
      Source sequence(s)
      BC037491, BX648833
      Consensus CDS
      CCDS9508.1
      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Related
      ENSP00000402030.1, OTTHUMP00000275088, ENST00000442234.5, OTTHUMT00000474726
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      108207442..108218368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020570.1XP_016876059.1  DNA ligase 4 isoform X3

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    2. XM_017020566.1XP_016876055.1  DNA ligase 4 isoform X1

    3. XM_011521091.2XP_011519393.1  DNA ligase 4 isoform X3

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    4. XM_017020565.1XP_016876054.1  DNA ligase 4 isoform X1

    5. XM_017020569.1XP_016876058.1  DNA ligase 4 isoform X3

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    6. XM_017020571.1XP_016876060.1  DNA ligase 4 isoform X3

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    7. XM_006719952.1XP_006720015.1  DNA ligase 4 isoform X3

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    8. XM_006719951.3XP_006720014.1  DNA ligase 4 isoform X3

      See identical proteins and their annotated locations for XP_006720014.1

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    9. XM_005254058.3XP_005254115.1  DNA ligase 4 isoform X3

      See identical proteins and their annotated locations for XP_005254115.1

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    10. XM_017020572.1XP_016876061.1  DNA ligase 4 isoform X4

      Related
      ENSP00000480814.1, OTTHUMP00000275090, ENST00000614526.1, OTTHUMT00000474728
      Conserved Domains (6) summary
      cd07968
      Location:392529
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:168388
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:14535
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:589663
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:1136
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:683716
      DNA_ligase_IV; DNA ligase IV
    11. XM_017020568.1XP_016876057.1  DNA ligase 4 isoform X2

    12. XM_017020563.1XP_016876052.1  DNA ligase 4 isoform X1

    13. XM_005254056.1XP_005254113.1  DNA ligase 4 isoform X3

      See identical proteins and their annotated locations for XP_005254113.1

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    14. XM_011521092.2XP_011519394.1  DNA ligase 4 isoform X3

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    15. XM_005254057.4XP_005254114.1  DNA ligase 4 isoform X3

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A024RE06
      Conserved Domains (6) summary
      cd07968
      Location:459596
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:235455
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:81602
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:656730
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:15203
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:750783
      DNA_ligase_IV; DNA ligase IV
    16. XM_017020567.1XP_016876056.1  DNA ligase 4 isoform X1

    17. XM_017020573.1XP_016876062.1  DNA ligase 4 isoform X4

      UniProtKB/Swiss-Prot
      P49917
      UniProtKB/TrEMBL
      A0A0C4DGV9
      Conserved Domains (6) summary
      cd07968
      Location:392529
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:168388
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      TIGR00574
      Location:14535
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:589663
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:1136
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:683716
      DNA_ligase_IV; DNA ligase IV
    18. XM_017020564.1XP_016876053.1  DNA ligase 4 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      108828932..108839838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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