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    DZIP3 DAZ interacting zinc finger protein 3 [ Homo sapiens (human) ]

    Gene ID: 9666, updated on 4-Nov-2018

    Summary

    Official Symbol
    DZIP3provided by HGNC
    Official Full Name
    DAZ interacting zinc finger protein 3provided by HGNC
    Primary source
    HGNC:HGNC:30938
    See related
    Ensembl:ENSG00000198919 MIM:608672; Vega:OTTHUMG00000159232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UURF2; PPP1R66; hRUL138
    Expression
    Broad expression in testis (RPKM 21.6), brain (RPKM 12.1) and 21 other tissues See more
    Orthologs

    Genomic context

    See DZIP3 in Genome Data Viewer
    Location:
    3q13.13
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (108589490..108694846)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108308337..108413693)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 17 Neighboring gene HERV-H LTR-associating 2 Neighboring gene myosin heavy chain 15 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene cell proliferation regulating inhibitor of protein phosphatase 2A Neighboring gene uncharacterized LOC105374033 Neighboring gene uncharacterized LOC105374034

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ13327, FLJ57977, FLJ58022, FLJ58223, KIAA0675

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase DZIP3
    Names
    DAZ interacting protein 3, zinc finger
    DAZ-interacting protein 3
    RING-type E3 ubiquitin transferase DZIP3
    RNA-binding RING-H2 protein-ubiquitin ligase
    RNA-binding ubiquitin ligase of 138 kDa
    UURF2 ubiquitin ligase
    human RNA-binding ubiquitin ligase of 138 kDa
    protein phosphatase 1, regulatory subunit 66
    zinc finger DAZ interacting protein 3
    NP_055463.1
    XP_005247971.1
    XP_005247972.1
    XP_005247973.1
    XP_005247974.1
    XP_005247975.1
    XP_005247976.1
    XP_016863029.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014648.3NP_055463.1  E3 ubiquitin-protein ligase DZIP3

      See identical proteins and their annotated locations for NP_055463.1

      Status: VALIDATED

      Source sequence(s)
      AC092185, AC092693, AF279370, BC063882, BX495180, DA494378
      Consensus CDS
      CCDS2952.1
      UniProtKB/Swiss-Prot
      Q86Y13
      Related
      ENSP00000355028.3, OTTHUMP00000214428, ENST00000361582.7, OTTHUMT00000353968
      Conserved Domains (2) summary
      cd16460
      Location:11471188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675856
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      108589490..108694846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247918.3XP_005247975.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247975.1

      UniProtKB/Swiss-Prot
      Q86Y13
      Conserved Domains (2) summary
      cd16460
      Location:11471188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675856
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_005247917.3XP_005247974.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247974.1

      UniProtKB/Swiss-Prot
      Q86Y13
      Conserved Domains (2) summary
      cd16460
      Location:11471188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675856
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_005247919.4XP_005247976.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

      Conserved Domains (2) summary
      pfam12678
      Location:941982
      zf-rbx1; RING-H2 zinc finger
      pfam13639
      Location:942982
      zf-RING_2; Ring finger domain
    4. XM_005247914.4XP_005247971.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247971.1

      UniProtKB/Swiss-Prot
      Q86Y13
      Conserved Domains (2) summary
      cd16460
      Location:11471188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675856
      SMC_N; RecF/RecN/SMC N terminal domain
    5. XM_017007540.1XP_016863029.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      UniProtKB/Swiss-Prot
      Q86Y13
      Conserved Domains (2) summary
      cd16460
      Location:11471188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675856
      SMC_N; RecF/RecN/SMC N terminal domain
    6. XM_005247915.3XP_005247972.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247972.1

      UniProtKB/Swiss-Prot
      Q86Y13
      Related
      ENSP00000419981.1, OTTHUMP00000214430, ENST00000463306.1, OTTHUMT00000353971
      Conserved Domains (2) summary
      cd16460
      Location:11471188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675856
      SMC_N; RecF/RecN/SMC N terminal domain
    7. XM_005247916.3XP_005247973.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

      See identical proteins and their annotated locations for XP_005247973.1

      UniProtKB/Swiss-Prot
      Q86Y13
      Conserved Domains (2) summary
      cd16460
      Location:11471188
      RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
      cl25732
      Location:675856
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. XR_924222.2 RNA Sequence

    2. XR_001740382.1 RNA Sequence

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