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    TP53I3 tumor protein p53 inducible protein 3 [ Homo sapiens (human) ]

    Gene ID: 9540, updated on 15-Apr-2019

    Summary

    Official Symbol
    TP53I3provided by HGNC
    Official Full Name
    tumor protein p53 inducible protein 3provided by HGNC
    Primary source
    HGNC:HGNC:19373
    See related
    Ensembl:ENSG00000115129 MIM:605171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIG3
    Summary
    The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
    Expression
    Broad expression in esophagus (RPKM 29.3), small intestine (RPKM 17.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See TP53I3 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (24077428..24085767, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24300303..24308085, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WD repeat and coiled coil containing Neighboring gene FKBP prolyl isomerase 1B Neighboring gene RNA, U6 small nuclear 370, pseudogene Neighboring gene splicing factor 3b subunit 6 Neighboring gene family with sequence similarity 228 member B Neighboring gene profilin family member 4 Neighboring gene uncharacterized LOC105374328

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NADPH binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADPH:quinone reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    quinone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    NADP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    quinone oxidoreductase PIG3
    Names
    p53-induced gene 3 protein
    quinone oxidoreductase homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029715.1 RefSeqGene

      Range
      5001..12783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206802.2NP_001193731.1  quinone oxidoreductase PIG3 isoform 2

      See identical proteins and their annotated locations for NP_001193731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a coding exon in the 3' region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. This variant lacks the 5'-most non-coding exon because of alternate splicing, the extension at the 5' end is uncertain.
      Source sequence(s)
      AK223382, AY371700, CN285566
      Consensus CDS
      CCDS56112.1
      UniProtKB/Swiss-Prot
      Q53FA7
      Related
      ENSP00000384414.1, ENST00000407482.5
      Conserved Domains (1) summary
      cl16912
      Location:1205
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    2. NM_004881.5NP_004872.2  quinone oxidoreductase PIG3 isoform 1

      See identical proteins and their annotated locations for NP_004872.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
      Source sequence(s)
      AK223382, BT007149, CN285566
      Consensus CDS
      CCDS1708.1
      UniProtKB/Swiss-Prot
      Q53FA7
      Related
      ENSP00000238721.4, ENST00000238721.9
      Conserved Domains (1) summary
      cd05276
      Location:1328
      p53_inducible_oxidoreductase; PIG3 p53-inducible quinone oxidoreductase
    3. NM_147184.3NP_671713.1  quinone oxidoreductase PIG3 isoform 1

      See identical proteins and their annotated locations for NP_671713.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5'UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC000474, CN285566, DB032484, DB034176
      Consensus CDS
      CCDS1708.1
      UniProtKB/Swiss-Prot
      Q53FA7
      Related
      ENSP00000337834.4, ENST00000335934.8
      Conserved Domains (1) summary
      cd05276
      Location:1328
      p53_inducible_oxidoreductase; PIG3 p53-inducible quinone oxidoreductase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      24077428..24085767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264650.3XP_005264707.1  quinone oxidoreductase PIG3 isoform X2

      See identical proteins and their annotated locations for XP_005264707.1

      UniProtKB/TrEMBL
      B4DMQ7
      Conserved Domains (1) summary
      cl16912
      Location:48239
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    2. XM_024453249.1XP_024309017.1  quinone oxidoreductase PIG3 isoform X2

      Conserved Domains (1) summary
      cl16912
      Location:48239
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    3. XM_006712150.2XP_006712213.1  quinone oxidoreductase PIG3 isoform X1

      See identical proteins and their annotated locations for XP_006712213.1

      UniProtKB/Swiss-Prot
      Q53FA7
      Conserved Domains (1) summary
      cl16912
      Location:1205
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
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