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    IL32 interleukin 32 [ Homo sapiens (human) ]

    Gene ID: 9235, updated on 12-May-2019

    Summary

    Official Symbol
    IL32provided by HGNC
    Official Full Name
    interleukin 32provided by HGNC
    Primary source
    HGNC:HGNC:16830
    See related
    Ensembl:ENSG00000008517 MIM:606001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma
    Summary
    This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in small intestine (RPKM 122.1), spleen (RPKM 121.0) and 22 other tissues See more
    Orthologs

    Genomic context

    See IL32 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (3065312..3069819)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3115313..3119668)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128770 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene matrix metallopeptidase 25 Neighboring gene MMP25 antisense RNA 1 Neighboring gene RNA, U1 small nuclear 125, pseudogene Neighboring gene uncharacterized LOC107984896 Neighboring gene uncharacterized LOC105371058 Neighboring gene RNA, U1 small nuclear 22, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef IL-32-treated M2-macrophages inhibit the strong activation of p38, IKK alpha/beta, and TAK1 by HIV-1 Nef PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 

    General protein information

    Preferred Names
    interleukin-32
    Names
    interleukin-32 eta
    interleukin-32 small
    interleukin-32 theta
    natural killer cell transcript 4
    natural killer cells protein 4
    tumor necrosis factor alpha-inducing factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029254.1 RefSeqGene

      Range
      5001..9356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012631.2NP_001012649.1  interleukin-32 isoform B

      See identical proteins and their annotated locations for NP_001012649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (B), also referred to as IL-32beta.
      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS32377.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000432850.2, ENST00000528163.6
      Conserved Domains (1) summary
      pfam15225
      Location:69164
      IL32; Interleukin 32
    2. NM_001012632.1NP_001012650.1  interleukin-32 isoform B

      See identical proteins and their annotated locations for NP_001012650.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein, isoform B, also referred to as IL-32beta.
      Source sequence(s)
      AC108134, W57940
      Consensus CDS
      CCDS32377.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000411958.3, ENST00000444393.7
      Conserved Domains (1) summary
      pfam15225
      Location:69164
      IL32; Interleukin 32
    3. NM_001012633.2NP_001012651.1  interleukin-32 isoform A

      See identical proteins and their annotated locations for NP_001012651.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 5' UTR and contains an alternate intron within the last exon of the coding region, compared to variant 1. The encoded isoform (A), also referred to as IL-32alpha, is shorter compared to isoform B.
      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS32378.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000380096.3, ENST00000396887.7
      Conserved Domains (1) summary
      pfam15225
      Location:69107
      IL32; Interleukin 32
    4. NM_001012634.2NP_001012652.1  interleukin-32 isoform C

      See identical proteins and their annotated locations for NP_001012652.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 5' UTR and an alternate in-frame exon within the coding region, compared to variant 1, resulting in a shorter protein (isoform C).
      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS45394.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000008180.9, ENST00000008180.13
      Conserved Domains (1) summary
      pfam15225
      Location:49144
      IL32; Interleukin 32
    5. NM_001012635.2NP_001012653.1  interleukin-32 isoform C

      See identical proteins and their annotated locations for NP_001012653.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon within the coding region, compared to variant 1, resulting in a shorter protein (isoform C).
      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS45394.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000433747.1, ENST00000530890.5
      Conserved Domains (1) summary
      pfam15225
      Location:49144
      IL32; Interleukin 32
    6. NM_001012636.1NP_001012654.1  interleukin-32 isoform D

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate exons in the 5' UTR and an alternate in-frame exon within the coding region, compared to variant 1, resulting in a shorter protein (isoform D). Please note that isoform D is not the same as isoform delta, which is represented by AY495333.1.
      Source sequence(s)
      AC108134, W57940
      Consensus CDS
      CCDS32379.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000371648.3, ENST00000382213.7
      Conserved Domains (1) summary
      pfam15225
      Location:60155
      IL32; Interleukin 32
    7. NM_001012718.2NP_001012736.1  interleukin-32 isoform B

      See identical proteins and their annotated locations for NP_001012736.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains an alternate in-frame splice site in the 5' UTR compared to variant 1. Variants 1 and 8 encode the same protein, isoform B, also referred to as IL-32beta.
      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS32377.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000405063.3, ENST00000440815.7
      Conserved Domains (1) summary
      pfam15225
      Location:69164
      IL32; Interleukin 32
    8. NM_001308078.2NP_001295007.1  interleukin-32 isoform E precursor

      See identical proteins and their annotated locations for NP_001295007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has a shorter 5' UTR and contains an additional segment in the central coding region compared to variant 1. The encoded isoform (E) is longer than isoform B.
      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS76811.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000380099.2, ENST00000396890.6
      Conserved Domains (1) summary
      pfam15225
      Location:115210
      IL32; Interleukin 32
    9. NM_001369587.1NP_001356516.1  interleukin-32 isoform E

      Status: REVIEWED

      Source sequence(s)
      AC108134
    10. NM_001369588.1NP_001356517.1  interleukin-32 isoform E

      Status: REVIEWED

      Source sequence(s)
      AC108134
    11. NM_001369589.1NP_001356518.1  interleukin-32 isoform B

      Status: REVIEWED

      Source sequence(s)
      AC108134
    12. NM_001369590.1NP_001356519.1  interleukin-32 isoform C

      Status: REVIEWED

      Source sequence(s)
      AC108134
    13. NM_001369591.1NP_001356520.1  interleukin-32 isoform C

      Status: REVIEWED

      Source sequence(s)
      AC108134
    14. NM_001369592.1NP_001356521.1  interleukin-32 isoform C

      Status: REVIEWED

      Source sequence(s)
      AC108134
    15. NM_001369593.1NP_001356522.1  interleukin-32 isoform F

      Status: REVIEWED

      Source sequence(s)
      AC108134
    16. NM_001369595.1NP_001356524.1  interleukin-32 isoform G

      Status: REVIEWED

      Source sequence(s)
      AC108134
    17. NM_001369596.1NP_001356525.1  interleukin-32 isoform B

      Status: REVIEWED

      Source sequence(s)
      AC108134
    18. NM_004221.5NP_004212.4  interleukin-32 isoform B

      See identical proteins and their annotated locations for NP_004212.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein, isoform B, also referred to as IL-32beta.
      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS32377.1
      UniProtKB/Swiss-Prot
      P24001
      Related
      ENSP00000324742.5, ENST00000325568.9
      Conserved Domains (1) summary
      pfam15225
      Location:69164
      IL32; Interleukin 32

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      3065312..3069819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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