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    LATS1 large tumor suppressor kinase 1 [ Homo sapiens (human) ]

    Gene ID: 9113, updated on 7-Jul-2019

    Summary

    Official Symbol
    LATS1provided by HGNC
    Official Full Name
    large tumor suppressor kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:6514
    See related
    Ensembl:ENSG00000131023 MIM:603473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    wts; WARTS
    Summary
    The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See LATS1 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149658153..149718256, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149979289..150039392, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S18 pseudogene 9 Neighboring gene katanin catalytic subunit A1 Neighboring gene uncharacterized LOC105378050 Neighboring gene uncharacterized LOC645967 Neighboring gene nucleoporin 43 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene BTB domain containing 10 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Hippo signaling, organism-specific biosystem (from KEGG)
      Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Hippo signaling, conserved biosystem (from KEGG)
      Hippo signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
      Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
    • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
      Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
      Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Hippo, organism-specific biosystem (from REACTOME)
      Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic sequestering of protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hippo signaling TAS
    Traceable Author Statement
    more info
     
    hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inner cell mass cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    inner cell mass cellular morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of intracellular estrogen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase LATS1
    Names
    LATS (large tumor suppressor, Drosophila) homolog 1
    LATS, large tumor suppressor, homolog 1
    WARTS protein kinase
    h-warts
    large tumor suppressor homolog 1
    NP_001257448.1
    NP_001337268.1
    NP_001337269.1
    NP_001337321.1
    NP_004681.1
    XP_006715666.1
    XP_011534554.1
    XP_016866963.1
    XP_016866966.1
    XP_016866968.1
    XP_016866969.1
    XP_016866971.1
    XP_024302351.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270519.1NP_001257448.1  serine/threonine-protein kinase LATS1 isoform 2

      See identical proteins and their annotated locations for NP_001257448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the last four exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF104413, AL358852, AL583963, BC002767
      Consensus CDS
      CCDS59040.1
      UniProtKB/Swiss-Prot
      O95835
      Related
      ENSP00000444678.1, ENST00000392273.7
      Conserved Domains (3) summary
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl26247
      Location:473558
      DNA_pol3_delta2; DNA polymerase III, delta subunit
      cl28087
      Location:467673
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    2. NM_001350339.2NP_001337268.1  serine/threonine-protein kinase LATS1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform 3.
      Source sequence(s)
      AL358852, AL583963, BX276089
      Conserved Domains (3) summary
      cl21453
      Location:5981012
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:1138
      UBA_like_SF; UBA domain-like superfamily
      cl28087
      Location:343491
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    3. NM_001350340.2NP_001337269.1  serine/threonine-protein kinase LATS1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes isoform 4.
      Source sequence(s)
      AL358852, AL583963, BX276089
      Conserved Domains (3) summary
      cd05625
      Location:598979
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl21463
      Location:1138
      UBA_like_SF; UBA domain-like superfamily
      cl28087
      Location:343491
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    4. NM_001350392.2NP_001337321.1  serine/threonine-protein kinase LATS1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes isoform 5.
      Source sequence(s)
      AL358852, AL583963, BX276089
      Conserved Domains (2) summary
      cd05625
      Location:423804
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl26464
      Location:9312
      Atrophin-1; Atrophin-1 family
    5. NM_004690.4NP_004681.1  serine/threonine-protein kinase LATS1 isoform 1

      See identical proteins and their annotated locations for NP_004681.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF104413, AL358852, AW021064, BX276089
      Consensus CDS
      CCDS34551.1
      UniProtKB/Swiss-Prot
      O95835
      Related
      ENSP00000437550.1, ENST00000543571.6
      Conserved Domains (3) summary
      smart00220
      Location:7051010
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cd05625
      Location:7031084
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

    RNA

    1. NR_073033.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.
      Source sequence(s)
      AK310422, AW021064, BX276089

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      149658153..149718256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011474.1XP_016866963.1  serine/threonine-protein kinase LATS1 isoform X1

      Conserved Domains (3) summary
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:7031117
      PKc_like; Protein Kinases, catalytic domain
      cl28087
      Location:448596
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    2. XM_017011480.1XP_016866969.1  serine/threonine-protein kinase LATS1 isoform X6

    3. XM_024446583.1XP_024302351.1  serine/threonine-protein kinase LATS1 isoform X1

      Conserved Domains (3) summary
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:7031117
      PKc_like; Protein Kinases, catalytic domain
      cl28087
      Location:448596
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    4. XM_017011479.1XP_016866968.1  serine/threonine-protein kinase LATS1 isoform X4

    5. XM_017011477.1XP_016866966.1  serine/threonine-protein kinase LATS1 isoform X2

    6. XM_011536252.2XP_011534554.1  serine/threonine-protein kinase LATS1 isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:705961
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:703961
      PKc_like; Protein Kinases, catalytic domain
    7. XM_006715603.3XP_006715666.1  serine/threonine-protein kinase LATS1 isoform X5

      Conserved Domains (3) summary
      smart00220
      Location:705862
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:703863
      PKc_like; Protein Kinases, catalytic domain
    8. XM_017011482.1XP_016866971.1  serine/threonine-protein kinase LATS1 isoform X7

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