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    EIF3A eukaryotic translation initiation factor 3 subunit A [ Homo sapiens (human) ]

    Gene ID: 8661, updated on 7-Oct-2018

    Summary

    Official Symbol
    EIF3Aprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Aprovided by HGNC
    Primary source
    HGNC:HGNC:3271
    See related
    Ensembl:ENSG00000107581 MIM:602039; Vega:OTTHUMG00000019144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta
    Expression
    Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See EIF3A in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (119033670..119080884, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120794541..120840959, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 36 Neighboring gene lactate dehydrogenase A pseudogene 5 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene Sharpr-MPRA regulatory region 2008 Neighboring gene family with sequence similarity 45 member A Neighboring gene sideroflexin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem (from REACTOME)
      Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystemThe cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF...
    • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
      Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
    • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
    • Formation of a pool of free 40S subunits, organism-specific biosystem (from REACTOME)
      Formation of a pool of free 40S subunits, organism-specific biosystemThe 80S ribosome dissociates into free 40S (small) and 60S (large) ribosomal subunits. Each ribosomal subunit is constituted by several individual ribosomal proteins and rRNA.
    • Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem (from REACTOME)
      Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystemBinding of the methionyl-tRNA initiator to the active eIF2:GTP complex results in the formation of the ternary complex. Subsequently, this Met-tRNAi:eIF2:GTP (ternary) complex binds to the complex fo...
    • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
      GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
      L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
      Ribosomal scanning and start codon recognition, organism-specific biosystemThe 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon o...
    • Translation, organism-specific biosystem (from REACTOME)
      Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
    • Translation initiation complex formation, organism-specific biosystem (from REACTOME)
      Translation initiation complex formation, organism-specific biosystemThe translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. e...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0139

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    IRES-dependent viral translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    formation of cytoplasmic translation initiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    formation of cytoplasmic translation initiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    translation reinitiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational initiation IC
    Inferred by Curator
    more info
    PubMed 
    translational initiation TAS
    Traceable Author Statement
    more info
     
    viral translational termination-reinitiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eukaryotic translation initiation factor 3 complex, eIF3e IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane HDA PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    multi-eIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit A
    Names
    EIF3, p180 subunit
    centrosomin homolog
    cytoplasmic protein p167
    eIF-3-theta
    eIF3 p167
    eIF3 p180
    eIF3 p185
    eukaryotic translation initiation factor 3 subunit 10
    eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)
    eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)
    eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa
    eukaryotic translation initiation factor 3, subunit 10, 170kD

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003750.3NP_003741.1  eukaryotic translation initiation factor 3 subunit A

      See identical proteins and their annotated locations for NP_003741.1

      Status: VALIDATED

      Source sequence(s)
      AL157788, AL355598
      Consensus CDS
      CCDS7608.1
      UniProtKB/Swiss-Prot
      Q14152
      Related
      ENSP00000358140.3, OTTHUMP00000020589, ENST00000369144.7
      Conserved Domains (6) summary
      smart00088
      Location:426498
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam16214
      Location:9801099
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cd16269
      Location:650661
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:643737
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:566685
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:516603
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      119033670..119080884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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