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    Ptp4a2 protein tyrosine phosphatase type IVA, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85237, updated on 21-Jul-2018

    Summary

    Official Symbol
    Ptp4a2provided by RGD
    Official Full Name
    protein tyrosine phosphatase type IVA, member 2provided by RGD
    Primary source
    RGD:619786
    See related
    Ensembl:ENSRNOG00000050044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    expression pattern in pituitary displays sexual dimorphism; may play a role in endocrine function [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 2304.0), Spleen (RPKM 1128.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ptp4a2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (148035501..148060752)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (151758017..151784448)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 39b Neighboring gene KH RNA binding domain containing, signal transduction associated 1 Neighboring gene SPOC domain containing 1 Neighboring gene adhesion G protein-coupled receptor B2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein tyrosine phosphatase type IVA 2
    Names
    PRL-2
    protein-tyrosine phosphatase 4a2
    protein-tyrosine phosphatase of regenerating liver 2
    NP_445927.1
    XP_017449153.1
    XP_017449154.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053475.1NP_445927.1  protein tyrosine phosphatase type IVA 2

      See identical proteins and their annotated locations for NP_445927.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ007016
      UniProtKB/Swiss-Prot
      Q6P9X4
      Related
      ENSRNOP00000064832.1, ENSRNOT00000074415.2
      Conserved Domains (1) summary
      cl21483
      Location:8157
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      148035501..148060752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593665.1XP_017449154.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9X4
      Conserved Domains (1) summary
      cl21483
      Location:8157
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_017593664.1XP_017449153.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9X4
      Conserved Domains (1) summary
      cl21483
      Location:8157
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      140653929..140663126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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