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    PPFIA1 PTPRF interacting protein alpha 1 [ Homo sapiens (human) ]

    Gene ID: 8500, updated on 26-Aug-2018

    Summary

    Official Symbol
    PPFIA1provided by HGNC
    Official Full Name
    PTPRF interacting protein alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:9245
    See related
    Ensembl:ENSG00000131626 MIM:611054; Vega:OTTHUMG00000167266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIP1; LIP.1; LIPRIN
    Summary
    The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 18.0), thyroid (RPKM 12.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See PPFIA1 in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (70270687..70384501)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70116806..70230607)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928473 Neighboring gene anoctamin 1 Neighboring gene uncharacterized LOC107984346 Neighboring gene uncharacterized LOC105369373 Neighboring gene Fas associated via death domain Neighboring gene H2A histone family member Z pseudogene 4 Neighboring gene uncharacterized LOC107984347 Neighboring gene microRNA 548k Neighboring gene cortactin Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene SHANK2 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with PFFIA1 as demonstrated by proximity dependent biotinylation proteomics PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystemAcetylcholine neurotransmitter release cycle involves syntheis of choline, loading of clathrin scultpted synaptic vesicles, docking and priming of the acetyl choline loaded synaptic vesicles and then...
    • Dopamine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Dopamine Neurotransmitter Release Cycle, organism-specific biosystemDopamine neurotransmitter cycle occurs in dopaminergic neurons. Dopamine is synthesized and loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and fused w...
    • Glutamate Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Glutamate Neurotransmitter Release Cycle, organism-specific biosystemCommunication at the synapse involves the release of glutamate from the presynaptic neuron and its binding to glutamate receptors on the postsynaptic cell to generate a series of events that lead to ...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Neurotransmitter Release Cycle, organism-specific biosystemNeurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotr...
    • Norepinephrine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Norepinephrine Neurotransmitter Release Cycle, organism-specific biosystemNoradrenalin release cycle consists of reacidification of the empty clathrin sculpted monoamine transport vesicle, loading of dopamine into reacidified clathrin coated monamine transport vesicle, con...
    • Serotonin Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Serotonin Neurotransmitter Release Cycle, organism-specific biosystemSerotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoa...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ41337, FLJ42630, FLJ43474, MGC26800

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    presynaptic active zone TAS
    Traceable Author Statement
    more info
    PubMed 
    protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    liprin-alpha-1
    Names
    LAR-interacting protein 1
    LIP-1
    Liprin-alpha1
    protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003626.3NP_003617.1  liprin-alpha-1 isoform b

      See identical proteins and their annotated locations for NP_003617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and it encodes the longer protein (isoform b).
      Source sequence(s)
      AK124621, AW163189, CK902590, U22816
      Consensus CDS
      CCDS31627.1
      UniProtKB/Swiss-Prot
      Q13136
      UniProtKB/TrEMBL
      B3KVS8
      Related
      ENSP00000253925.7, OTTHUMP00000235552, ENST00000253925.11, OTTHUMT00000393905
      Conserved Domains (6) summary
      cd09562
      Location:875945
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:9621027
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10471118
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:10481118
      SAM; Sterile alpha motif
      pfam12795
      Location:321517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_177423.2NP_803172.1  liprin-alpha-1 isoform a

      See identical proteins and their annotated locations for NP_803172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' end, which includes a part of the coding region and 3' UTR, as compared to variant 2. The resulting protein (isoform a) has a distinct and shorter C-terminus, as compared to isoform b.
      Source sequence(s)
      AW163189, BF352121, U22815
      Consensus CDS
      CCDS31628.1
      UniProtKB/Swiss-Prot
      Q13136
      Related
      ENSP00000374198.3, OTTHUMP00000235553, ENST00000389547.7, OTTHUMT00000393906
      Conserved Domains (6) summary
      cd09562
      Location:875945
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:9621027
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10471118
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:10481118
      SAM; Sterile alpha motif
      pfam12795
      Location:321517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. NR_045286.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in an internal exon and contains an alternate exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB209314, AW163189, CK902590, U22816
      Related
      ENST00000532504.5, OTTHUMT00000393907

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      70270687..70384501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545309.2XP_011543611.1  liprin-alpha-1 isoform X4

      Conserved Domains (6) summary
      cd09562
      Location:9491019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10661131
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11511222
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11521222
      SAM; Sterile alpha motif
      pfam00836
      Location:416524
      Stathmin; Stathmin family
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
    2. XM_006718716.3XP_006718779.1  liprin-alpha-1 isoform X1

      See identical proteins and their annotated locations for XP_006718779.1

      Conserved Domains (7) summary
      cd09562
      Location:9491019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10661131
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11511222
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11521222
      SAM; Sterile alpha motif
      pfam00836
      Location:416524
      Stathmin; Stathmin family
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_011545307.3XP_011543609.1  liprin-alpha-1 isoform X2

      Conserved Domains (7) summary
      cd09562
      Location:9491019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10571122
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11421213
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11431213
      SAM; Sterile alpha motif
      pfam00836
      Location:416524
      Stathmin; Stathmin family
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_011545311.3XP_011543613.1  liprin-alpha-1 isoform X6

      Conserved Domains (7) summary
      cd09562
      Location:9491019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10371102
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11221193
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11231193
      SAM; Sterile alpha motif
      pfam00836
      Location:416524
      Stathmin; Stathmin family
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_011545308.3XP_011543610.1  liprin-alpha-1 isoform X3

      Conserved Domains (7) summary
      cd09562
      Location:9391009
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10561121
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11411212
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11421212
      SAM; Sterile alpha motif
      pfam00836
      Location:416524
      Stathmin; Stathmin family
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_011545314.3XP_011543616.1  liprin-alpha-1 isoform X10

      Conserved Domains (6) summary
      cd09562
      Location:900970
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10171082
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11021173
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11031173
      SAM; Sterile alpha motif
      pfam00836
      Location:416524
      Stathmin; Stathmin family
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
    7. XM_011545310.3XP_011543612.1  liprin-alpha-1 isoform X5

      Conserved Domains (6) summary
      cd09562
      Location:924994
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10411106
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11261197
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11271197
      SAM; Sterile alpha motif
      pfam12795
      Location:321517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    8. XM_011545319.1XP_011543621.1  liprin-alpha-1 isoform X17

      Conserved Domains (6) summary
      cd09562
      Location:885955
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:9931058
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10781149
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:10791149
      SAM; Sterile alpha motif
      pfam12795
      Location:321517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    9. XM_011545312.2XP_011543614.1  liprin-alpha-1 isoform X7

      Conserved Domains (7) summary
      cd09562
      Location:9491019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10361101
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11211192
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11221192
      SAM; Sterile alpha motif
      pfam00836
      Location:416524
      Stathmin; Stathmin family
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    10. XM_017018448.1XP_016873937.1  liprin-alpha-1 isoform X9

    11. XM_011545316.2XP_011543618.1  liprin-alpha-1 isoform X12

      Conserved Domains (5) summary
      cd09562
      Location:910980
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:9971062
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10821153
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:10831153
      SAM; Sterile alpha motif
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
    12. XM_011545317.2XP_011543619.1  liprin-alpha-1 isoform X13

      Conserved Domains (5) summary
      cd09562
      Location:900970
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:9871052
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10721143
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:10731143
      SAM; Sterile alpha motif
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
    13. XM_017018449.1XP_016873938.1  liprin-alpha-1 isoform X14

    14. XM_011545313.2XP_011543615.1  liprin-alpha-1 isoform X8

      Conserved Domains (5) summary
      cd09562
      Location:910980
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10271092
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11121183
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11131183
      SAM; Sterile alpha motif
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
    15. XM_011545315.2XP_011543617.1  liprin-alpha-1 isoform X11

      Related
      ENSP00000496327.1, ENST00000644155.1
      Conserved Domains (6) summary
      cd09562
      Location:885955
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10021067
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10871158
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:10881158
      SAM; Sterile alpha motif
      pfam12795
      Location:321517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    16. XM_017018450.1XP_016873939.1  liprin-alpha-1 isoform X15

    17. XM_011545306.3XP_011543608.1  liprin-alpha-1 isoform X1

      See identical proteins and their annotated locations for XP_011543608.1

      Conserved Domains (7) summary
      cd09562
      Location:9491019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10661131
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11511222
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:11521222
      SAM; Sterile alpha motif
      pfam00836
      Location:416524
      Stathmin; Stathmin family
      pfam12795
      Location:321542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    18. XM_011545318.3XP_011543620.1  liprin-alpha-1 isoform X16

      Conserved Domains (4) summary
      cd09562
      Location:256326
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:373438
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:458529
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:459529
      SAM; Sterile alpha motif
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