Format

Send to:

Choose Destination
    • Showing Current items.

    HINT2 histidine triad nucleotide binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 84681, updated on 5-Aug-2018

    Summary

    Official Symbol
    HINT2provided by HGNC
    Official Full Name
    histidine triad nucleotide binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:18344
    See related
    Ensembl:ENSG00000137133 MIM:609997; Vega:OTTHUMG00000019886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIT-17
    Summary
    Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 37.3), fat (RPKM 32.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See HINT2 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (35812960..35815479, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35812957..35815481, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RGP1 homolog, RAB6A GEF complex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene natriuretic peptide receptor 2 Neighboring gene sperm associated antigen 8 Neighboring gene family with sequence similarity 221 member B Neighboring gene transmembrane protein 8B Neighboring gene olfactory receptor family 13 subfamily E member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-lysine acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    histidine triad nucleotide-binding protein 2, mitochondrial
    Names
    HINT-2
    HINT-3
    HIT-17kDa
    PKCI-1-related HIT protein
    protein kinase C inhibitor-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032593.2NP_115982.1  histidine triad nucleotide-binding protein 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_115982.1

      Status: VALIDATED

      Source sequence(s)
      BC047737, BI759951, BM764627
      Consensus CDS
      CCDS6594.1
      UniProtKB/Swiss-Prot
      Q9BX68
      Related
      ENSP00000259667.5, OTTHUMP00000021363, ENST00000259667.5, OTTHUMT00000052390
      Conserved Domains (1) summary
      cd01276
      Location:53155
      PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      35812960..35815479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447703.1XP_024303471.1  histidine triad nucleotide-binding protein 2, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00228
      Location:55135
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    2. XM_024447702.1XP_024303470.1  histidine triad nucleotide-binding protein 2, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd01276
      Location:55157
      PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...
    3. XM_024447704.1XP_024303472.1  histidine triad nucleotide-binding protein 2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00228
      Location:53133
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    Support Center