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    ZNF611 zinc finger protein 611 [ Homo sapiens (human) ]

    Gene ID: 81856, updated on 17-Jun-2019

    Summary

    Official Symbol
    ZNF611provided by HGNC
    Official Full Name
    zinc finger protein 611provided by HGNC
    Primary source
    HGNC:HGNC:28766
    See related
    Ensembl:ENSG00000213020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in kidney (RPKM 2.4), thyroid (RPKM 2.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF611 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52702813..52735054, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53206066..53238307, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 701 Neighboring gene zinc finger protein 137, pseudogene Neighboring gene zinc finger protein 83 Neighboring gene uncharacterized LOC105372452 Neighboring gene uncharacterized LOC105372451 Neighboring gene zinc finger protein 600

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC5384

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161499.2NP_001154971.1  zinc finger protein 611 isoform a

      See identical proteins and their annotated locations for NP_001154971.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC022150, BC028590, DA226106, DA245006, DA726181
      Consensus CDS
      CCDS12855.1
      UniProtKB/Swiss-Prot
      Q8N823
      Related
      ENSP00000437616.1, ENST00000543227.5
      Conserved Domains (5) summary
      smart00349
      Location:2460
      KRAB; krueppel associated box
      COG5048
      Location:256698
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:540560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2460
      KRAB; KRAB box
      pfam13465
      Location:665689
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001161500.1NP_001154972.1  zinc finger protein 611 isoform a

      See identical proteins and their annotated locations for NP_001154972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC022150, BC028590, DB122407
      Consensus CDS
      CCDS12855.1
      UniProtKB/Swiss-Prot
      Q8N823
      Related
      ENSP00000439211.1, ENST00000540744.5
      Conserved Domains (5) summary
      smart00349
      Location:2460
      KRAB; krueppel associated box
      COG5048
      Location:256698
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:540560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2460
      KRAB; KRAB box
      pfam13465
      Location:665689
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001161501.1NP_001154973.1  zinc finger protein 611 isoform b

      See identical proteins and their annotated locations for NP_001154973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC022150, BC028590, DA225124
      Consensus CDS
      CCDS54312.1
      UniProtKB/Swiss-Prot
      Q8N823
      Related
      ENSP00000443505.1, ENST00000453741.6
      Conserved Domains (3) summary
      COG5048
      Location:187629
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:471491
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:596620
      zf-H2C2_2; Zinc-finger double domain
    4. NM_030972.3NP_112234.3  zinc finger protein 611 isoform a

      See identical proteins and their annotated locations for NP_112234.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC022150, AK097434, BC028590, BC143996
      Consensus CDS
      CCDS12855.1
      UniProtKB/Swiss-Prot
      Q8N823
      Related
      ENSP00000322427.1, ENST00000319783.5
      Conserved Domains (5) summary
      smart00349
      Location:2460
      KRAB; krueppel associated box
      COG5048
      Location:256698
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:540560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2460
      KRAB; KRAB box
      pfam13465
      Location:665689
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      52702813..52735054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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