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    ZNF343 zinc finger protein 343 [ Homo sapiens (human) ]

    Gene ID: 79175, updated on 12-Aug-2018

    Summary

    Official Symbol
    ZNF343provided by HGNC
    Official Full Name
    zinc finger protein 343provided by HGNC
    Primary source
    HGNC:HGNC:16017
    See related
    Ensembl:ENSG00000088876 Vega:OTTHUMG00000031701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ734P14.5
    Expression
    Ubiquitous expression in endometrium (RPKM 3.1), ovary (RPKM 3.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF343 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (2481817..2524522, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2462463..2489778, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transglutaminase 6 Neighboring gene small nucleolar RNA, C/D box 119 Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 Neighboring gene uncharacterized LOC105372504 Neighboring gene transmembrane channel like 2 Neighboring gene uncharacterized LOC105372505

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ39592, MGC10715, MGC20504

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282495.1NP_001269424.1  zinc finger protein 343 isoform 1

      See identical proteins and their annotated locations for NP_001269424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 7 encode the same isoform (1).
      Source sequence(s)
      AL049712, BC065009, BQ212757
      Consensus CDS
      CCDS13028.1
      UniProtKB/Swiss-Prot
      Q6P1L6
      Conserved Domains (6) summary
      smart00349
      Location:62106
      KRAB; krueppel associated box
      COG5048
      Location:266593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:297319
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:396420
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001282496.1NP_001269425.1  zinc finger protein 343 isoform 1

      See identical proteins and their annotated locations for NP_001269425.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 7 encode the same isoform (1).
      Source sequence(s)
      AK096911, BC011862, BQ212757, CD702168, DB061474
      Consensus CDS
      CCDS13028.1
      UniProtKB/Swiss-Prot
      Q6P1L6
      Conserved Domains (6) summary
      smart00349
      Location:62106
      KRAB; krueppel associated box
      COG5048
      Location:266593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:297319
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:396420
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001282497.1NP_001269426.1  zinc finger protein 343 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is longer, compared to isoform 1. Both variants 4 and 8 encode the same isoform (2).
      Source sequence(s)
      BC065009, BQ212757, DA034001, DB061474, DR002765
      Consensus CDS
      CCDS74693.1
      UniProtKB/Swiss-Prot
      Q6P1L6
      UniProtKB/TrEMBL
      A0A087WZQ2
      Conserved Domains (6) summary
      smart00349
      Location:62102
      KRAB; krueppel associated box
      COG5048
      Location:307634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:396416
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:618640
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:437461
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001282498.1NP_001269427.1  zinc finger protein 343 isoform 3

      See identical proteins and their annotated locations for NP_001269427.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      BC065009, BQ212757, DA585339, DB061474
      Consensus CDS
      CCDS74692.1
      UniProtKB/Swiss-Prot
      Q6P1L6
      Related
      ENSP00000483851.1, ENST00000617391.4
      Conserved Domains (4) summary
      COG5048
      Location:176503
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265285
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:207229
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:306330
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001282499.1NP_001269428.1  zinc finger protein 343 isoform 4

      See identical proteins and their annotated locations for NP_001269428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC002897, DB061474
      Consensus CDS
      CCDS74694.1
      UniProtKB/Swiss-Prot
      Q6P1L6
      Related
      ENSP00000370652.1, OTTHUMP00000030027, ENST00000381253.5, OTTHUMT00000077616
      Conserved Domains (1) summary
      pfam01352
      Location:61102
      KRAB; KRAB box
    6. NM_001321800.1NP_001308729.1  zinc finger protein 343 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1-3 and 7 encode the same isoform (1).
      Source sequence(s)
      AL049650, BC011862, DB217060
      Consensus CDS
      CCDS13028.1
      UniProtKB/Swiss-Prot
      Q6P1L6
      Conserved Domains (6) summary
      smart00349
      Location:62106
      KRAB; krueppel associated box
      COG5048
      Location:266593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:297319
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:396420
      zf-H2C2_2; Zinc-finger double domain
    7. NM_001321801.1NP_001308730.1  zinc finger protein 343 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: Both variants 4 and 8 encode the same isoform (2).
      Source sequence(s)
      AL049650, BC011862, DB217060
      Consensus CDS
      CCDS74693.1
      UniProtKB/Swiss-Prot
      Q6P1L6
      UniProtKB/TrEMBL
      A0A087WZQ2
      Related
      ENSP00000482819.1, ENST00000612935.4
      Conserved Domains (6) summary
      smart00349
      Location:62102
      KRAB; krueppel associated box
      COG5048
      Location:307634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:396416
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:618640
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:437461
      zf-H2C2_2; Zinc-finger double domain
    8. NM_001321802.1NP_001308731.1  zinc finger protein 343 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL049650, AL133339, BC011862, DB061474
      UniProtKB/Swiss-Prot
      Q6P1L6
      Conserved Domains (6) summary
      smart00349
      Location:62102
      KRAB; krueppel associated box
      COG5048
      Location:306633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:395415
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:617639
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:436460
      zf-H2C2_2; Zinc-finger double domain
    9. NM_001321803.1NP_001308732.1  zinc finger protein 343 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL049650, BC011862, DB217060
      UniProtKB/Swiss-Prot
      Q6P1L6
      Conserved Domains (6) summary
      smart00349
      Location:62102
      KRAB; krueppel associated box
      COG5048
      Location:306633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:395415
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:617639
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:436460
      zf-H2C2_2; Zinc-finger double domain
    10. NM_001321805.1NP_001308734.1  zinc finger protein 343 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL049650, AL133339, BC011862, DB061474
      UniProtKB/Swiss-Prot
      Q6P1L6
      Conserved Domains (6) summary
      smart00349
      Location:62106
      KRAB; krueppel associated box
      COG5048
      Location:265592
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:354374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:296318
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:395419
      zf-H2C2_2; Zinc-finger double domain
    11. NM_024325.5NP_077301.4  zinc finger protein 343 isoform 1

      See identical proteins and their annotated locations for NP_077301.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1). Variants 1-3 and 7 encode the same isoform (1).
      Source sequence(s)
      AK096911, BC011862, BQ212757, DB061474, DR002765
      Consensus CDS
      CCDS13028.1
      UniProtKB/Swiss-Prot
      Q6P1L6
      Related
      ENSP00000278772.4, OTTHUMP00000030028, ENST00000278772.8, OTTHUMT00000077617
      Conserved Domains (6) summary
      smart00349
      Location:62106
      KRAB; krueppel associated box
      COG5048
      Location:266593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:297319
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:62101
      KRAB; KRAB box
      pfam13465
      Location:396420
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

      Range
      2481817..2524522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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