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    Zbtb49 zinc finger and BTB domain containing 49 [ Mus musculus (house mouse) ]

    Gene ID: 75079, updated on 18-Nov-2018

    Summary

    Official Symbol
    Zbtb49provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 49provided by MGI
    Primary source
    MGI:MGI:1922329
    See related
    Ensembl:ENSMUSG00000029127 Vega:OTTMUSG00000023309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp509; Znf509; 4930518A03Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 2.7), whole brain E14.5 (RPKM 2.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Zbtb49 in Genome Data Viewer
    Location:
    5; 5 B3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (38189732..38220449, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (38591283..38611667, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40289 Neighboring gene syntaxin 18 Neighboring gene neuron specific gene family member 1 Neighboring gene Ly1 antibody reactive clone Neighboring gene transmembrane protein 128

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 49
    Names
    zinc finger protein 509

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359466.1NP_001346395.1  zinc finger and BTB domain-containing protein 49 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC115931
      Conserved Domains (2) summary
      COG5048
      Location:78235
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:160180
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_029162.3NP_083438.1  zinc finger and BTB domain-containing protein 49 isoform 1

      See identical proteins and their annotated locations for NP_083438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC115931
      Consensus CDS
      CCDS19252.1
      UniProtKB/Swiss-Prot
      Q8BXX2
      Related
      ENSMUSP00000092429.3, OTTMUSP00000027133, ENSMUST00000094833.9
      Conserved Domains (6) summary
      smart00225
      Location:26119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:376576
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500520
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:386408
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:15118
      BTB; BTB/POZ domain
      pfam13465
      Location:540565
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_153116.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC115931

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      38189732..38220449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504163.2XP_006504226.1  zinc finger and BTB domain-containing protein 49 isoform X1

      Conserved Domains (6) summary
      smart00225
      Location:26119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:375536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:388408
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:386408
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:15118
      BTB; BTB/POZ domain
      pfam13465
      Location:400425
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006504165.3XP_006504228.1  zinc finger and BTB domain-containing protein 49 isoform X2

      UniProtKB/Swiss-Prot
      Q8BXX2
      Conserved Domains (2) summary
      COG5048
      Location:78235
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:160180
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_006504168.3XP_006504231.1  zinc finger and BTB domain-containing protein 49 isoform X5

      Conserved Domains (4) summary
      COG5048
      Location:6176
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:101121
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1537
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:141166
      zf-H2C2_2; Zinc-finger double domain
    4. XM_006504166.1XP_006504229.1  zinc finger and BTB domain-containing protein 49 isoform X4

      See identical proteins and their annotated locations for XP_006504229.1

      Conserved Domains (4) summary
      COG5048
      Location:20183
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:108128
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:2244
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:148173
      zf-H2C2_2; Zinc-finger double domain
    5. XM_011240782.1XP_011239084.1  zinc finger and BTB domain-containing protein 49 isoform X6

      Conserved Domains (3) summary
      COG5048
      Location:1151
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:7696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:116141
      zf-H2C2_2; Zinc-finger double domain
    6. XM_011240780.1XP_011239082.1  zinc finger and BTB domain-containing protein 49 isoform X3

      Conserved Domains (4) summary
      smart00225
      Location:26119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:388408
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:386408
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:15118
      BTB; BTB/POZ domain
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