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    Wdr35 WD repeat domain 35 [ Mus musculus (house mouse) ]

    Gene ID: 74682, updated on 31-Jan-2019

    Summary

    Official Symbol
    Wdr35provided by MGI
    Official Full Name
    WD repeat domain 35provided by MGI
    Primary source
    MGI:MGI:1921932
    See related
    Ensembl:ENSMUSG00000066643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1336; 4931430C06; 4930459M12Rik
    Expression
    Broad expression in testis adult (RPKM 14.6), CNS E18 (RPKM 6.0) and 15 other tissues See more
    Orthologs

    Genomic context

    See Wdr35 in Genome Data Viewer
    Location:
    12; 12 A1.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (8973992..9028848)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (8980807..9035653)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene lysosomal-associated protein transmembrane 4A Neighboring gene matrilin 3 Neighboring gene tetratricopeptide repeat domain 32 Neighboring gene predicted gene, 46323

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1336

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intraciliary retrograde transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intraciliary transport particle A IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intraciliary transport particle A ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 35

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159527.1NP_001152999.1  WD repeat-containing protein 35 isoform 2

      See identical proteins and their annotated locations for NP_001152999.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK029896, BC056925
      Consensus CDS
      CCDS49027.1
      UniProtKB/Swiss-Prot
      Q8BND3
      Related
      ENSMUSP00000106742.2, ENSMUST00000111113.2
      Conserved Domains (2) summary
      COG2319
      Location:7217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1869
      7WD40; WD40 repeat [structural motif]
    2. NM_172470.3NP_766058.3  WD repeat-containing protein 35 isoform 1

      See identical proteins and their annotated locations for NP_766058.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK029896, BC056925
      Consensus CDS
      CCDS25807.1
      UniProtKB/Swiss-Prot
      Q8BND3
      Related
      ENSMUSP00000082895.6, ENSMUST00000085745.12
      Conserved Domains (2) summary
      COG2319
      Location:7217
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1869
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      8973992..9028848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515232.2XP_006515295.1  WD repeat-containing protein 35 isoform X1

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