Format

Send to:

Choose Destination
    • Showing Current items.

    RGPD6 RANBP2-like and GRIP domain containing 6 [ Homo sapiens (human) ]

    Gene ID: 729540, updated on 2-Oct-2018

    Summary

    Official Symbol
    RGPD6provided by HGNC
    Official Full Name
    RANBP2-like and GRIP domain containing 6provided by HGNC
    Primary source
    HGNC:HGNC:32419
    See related
    Ensembl:ENSG00000183054 MIM:612709; Vega:OTTHUMG00000153196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGP6; RGPD7; RanBP2L1; RanBP2L2
    Expression
    Broad expression in testis (RPKM 24.0), brain (RPKM 8.3) and 25 other tissues See more

    Genomic context

    See RGPD6 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (110513802..110610903, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111271379..111336309, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LIM zinc finger domain containing 4 Neighboring gene uncharacterized LOC105373552 Neighboring gene uncharacterized LOC102724875 Neighboring gene uncharacterized LOC105373553 Neighboring gene ribosomal protein L22 pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC190070

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Ran GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    RANBP2-like and GRIP domain-containing protein 5/6
    Names
    RANBP2-like and GRIP domain-containing protein 7
    ran-binding protein 2-like 1/2
    ranBP2-like 1/2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037866.1NP_001032955.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 2

      See identical proteins and their annotated locations for NP_001032955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC123886
      Consensus CDS
      CCDS42729.1
      UniProtKB/Swiss-Prot
      Q99666
      Related
      ENSP00000330023.5, OTTHUMP00000225220, ENST00000330331.9, OTTHUMT00000376100
      Conserved Domains (3) summary
      sd00006
      Location:5989
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:6092
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:59126
      TPR_11; TPR repeat
    2. NM_001123363.3NP_001116835.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 1

      See identical proteins and their annotated locations for NP_001116835.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC108938, AC226101
      Consensus CDS
      CCDS46388.1
      UniProtKB/Swiss-Prot
      Q99666
      UniProtKB/TrEMBL
      V9HWE4
      Related
      ENSP00000330842.3, OTTHUMP00000216489, ENST00000329516.7, OTTHUMT00000330029
      Conserved Domains (8) summary
      COG5171
      Location:9751167
      YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
      cd13177
      Location:10511167
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13481464
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:5989
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:6092
      TPR_1; Tetratricopeptide repeat
      pfam01465
      Location:17071749
      GRIP; GRIP domain
      pfam13414
      Location:59126
      TPR_11; TPR repeat
      pfam16704
      Location:16411705
      Rab_bind; Rab binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      110513802..110610903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511766.2XP_011510068.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X2

      Conserved Domains (8) summary
      COG5171
      Location:10041196
      YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
      cd13177
      Location:10801196
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13771493
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:88118
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:89121
      TPR_1; Tetratricopeptide repeat
      pfam01465
      Location:17361778
      GRIP; GRIP domain
      pfam13414
      Location:88155
      TPR_11; TPR repeat
      pfam16704
      Location:16701734
      Rab_bind; Rab binding domain
    2. XM_017004842.1XP_016860331.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X5

    3. XM_017004839.1XP_016860328.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1

    4. XM_017004840.2XP_016860329.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X3

    5. XM_017004841.1XP_016860330.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X4

    6. XM_024453119.1XP_024308887.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X9

      Conserved Domains (2) summary
      cd13177
      Location:396512
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:693809
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    7. XM_011511770.2XP_011510072.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X8

      Conserved Domains (6) summary
      COG5171
      Location:10041196
      YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
      cd13177
      Location:10801196
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13771493
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:88118
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:89121
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:88155
      TPR_11; TPR repeat
    8. XM_011511769.2XP_011510071.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X6

      Conserved Domains (6) summary
      COG5171
      Location:10041196
      YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
      cd13177
      Location:10801196
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13771493
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:88118
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:89121
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:88155
      TPR_11; TPR repeat
    9. XM_017004843.1XP_016860332.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X7

    Support Center