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    Dhx30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 [ Mus musculus (house mouse) ]

    Gene ID: 72831, updated on 8-Dec-2018

    Summary

    Official Symbol
    Dhx30provided by MGI
    Official Full Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 30provided by MGI
    Primary source
    MGI:MGI:1920081
    See related
    Ensembl:ENSMUSG00000032480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HELG; Ddx30; Ret-CoR; 2810477H02Rik; C130058C04Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 35.3), whole brain E14.5 (RPKM 33.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dhx30 in Genome Data Viewer
    Location:
    9; 9 F2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (110084319..110117616, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (109986824..110018086, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene 4644 Neighboring gene microtubule-associated protein 4 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Neighboring gene 4.5s RNA, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 3'-5' RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP-dependent DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP-dependent RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    G-quadruplex RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    central nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial large ribosomal subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DHX30; putative ATP-dependent RNA helicase DHX30
    Names
    DEAH box protein 30
    NP_001239611.1
    NP_001239612.1
    NP_579925.1
    XP_006512361.1
    XP_006512362.1
    XP_006512363.1
    XP_006512364.1
    XP_006512366.1
    XP_006512367.1
    XP_006512368.1
    XP_006512373.1
    XP_011241331.1
    XP_017169102.1
    XP_017169103.1
    XP_017169104.1
    XP_017169105.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252682.1NP_001239611.1  ATP-dependent RNA helicase DHX30 isoform 1

      See identical proteins and their annotated locations for NP_001239611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1).
      Source sequence(s)
      AC159372, AK159601, BY540912, CF724787
      Consensus CDS
      CCDS57706.1
      UniProtKB/Swiss-Prot
      Q99PU8
      Related
      ENSMUSP00000142549.1, ENSMUST00000197928.4
      Conserved Domains (5) summary
      smart00490
      Location:686785
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:438617
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:857940
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:452593
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:9801102
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    2. NM_001252683.1NP_001239612.1  ATP-dependent RNA helicase DHX30 isoform 3

      See identical proteins and their annotated locations for NP_001239612.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BC016202, BY540912, CJ074324
      Consensus CDS
      CCDS57705.1
      UniProtKB/Swiss-Prot
      Q99PU8
      Related
      ENSMUSP00000062622.6, ENSMUST00000062368.12
      Conserved Domains (5) summary
      smart00490
      Location:715814
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:467646
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:886969
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:481622
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10091131
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    3. NM_133347.2NP_579925.1  ATP-dependent RNA helicase DHX30 isoform 2

      See identical proteins and their annotated locations for NP_579925.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB047557, BY540912
      Consensus CDS
      CCDS23560.1
      UniProtKB/Swiss-Prot
      Q99PU8
      Related
      ENSMUSP00000129174.1, ENSMUST00000165596.7
      Conserved Domains (5) summary
      smart00490
      Location:709808
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:461640
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:880963
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:475616
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10031125
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      110084319..110117616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512301.3XP_006512364.1  putative ATP-dependent RNA helicase DHX30 isoform X1

      See identical proteins and their annotated locations for XP_006512364.1

      UniProtKB/Swiss-Prot
      Q99PU8
      Conserved Domains (5) summary
      smart00490
      Location:709808
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:461640
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:880963
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:475616
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10031125
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    2. XM_006512305.3XP_006512368.1  putative ATP-dependent RNA helicase DHX30 isoform X2

      See identical proteins and their annotated locations for XP_006512368.1

      UniProtKB/Swiss-Prot
      Q99PU8
      Related
      ENSMUSP00000142489.1, ENSMUST00000199529.4
      Conserved Domains (5) summary
      smart00490
      Location:686785
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:438617
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:857940
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:452593
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:9801102
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    3. XM_006512298.3XP_006512361.1  putative ATP-dependent RNA helicase DHX30 isoform X1

      See identical proteins and their annotated locations for XP_006512361.1

      UniProtKB/Swiss-Prot
      Q99PU8
      Related
      ENSMUSP00000142659.1, ENSMUST00000198425.4
      Conserved Domains (5) summary
      smart00490
      Location:709808
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:461640
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:880963
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:475616
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10031125
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    4. XM_006512310.3XP_006512373.1  putative ATP-dependent RNA helicase DHX30 isoform X3

      See identical proteins and their annotated locations for XP_006512373.1

      UniProtKB/TrEMBL
      A0A0G2JGL8
      Related
      ENSMUSP00000143616.1, ENSMUST00000196171.4
      Conserved Domains (5) summary
      smart00490
      Location:678777
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:430609
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:849932
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:444585
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:9721094
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    5. XM_017313613.1XP_017169102.1  putative ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q99PU8
      Conserved Domains (5) summary
      smart00490
      Location:709808
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:461640
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:880963
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:475616
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10031125
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    6. XM_011243029.2XP_011241331.1  putative ATP-dependent RNA helicase DHX30 isoform X1

      See identical proteins and their annotated locations for XP_011241331.1

      UniProtKB/Swiss-Prot
      Q99PU8
      Conserved Domains (5) summary
      smart00490
      Location:709808
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:461640
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:880963
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:475616
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10031125
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    7. XM_006512300.1XP_006512363.1  putative ATP-dependent RNA helicase DHX30 isoform X1

      See identical proteins and their annotated locations for XP_006512363.1

      UniProtKB/Swiss-Prot
      Q99PU8
      Conserved Domains (5) summary
      smart00490
      Location:709808
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:461640
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:880963
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:475616
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10031125
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    8. XM_006512304.1XP_006512367.1  putative ATP-dependent RNA helicase DHX30 isoform X2

      See identical proteins and their annotated locations for XP_006512367.1

      UniProtKB/Swiss-Prot
      Q99PU8
      Conserved Domains (5) summary
      smart00490
      Location:686785
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:438617
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:857940
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:452593
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:9801102
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    9. XM_017313614.1XP_017169103.1  putative ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q99PU8
      Conserved Domains (5) summary
      smart00490
      Location:709808
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:461640
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:880963
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:475616
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10031125
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    10. XM_017313616.1XP_017169105.1  putative ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8
      Conserved Domains (5) summary
      smart00490
      Location:678777
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:430609
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:849932
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:444585
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:9721094
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    11. XM_006512299.1XP_006512362.1  putative ATP-dependent RNA helicase DHX30 isoform X1

      See identical proteins and their annotated locations for XP_006512362.1

      UniProtKB/Swiss-Prot
      Q99PU8
      Conserved Domains (5) summary
      smart00490
      Location:709808
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:461640
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:880963
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:475616
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:10031125
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    12. XM_006512303.1XP_006512366.1  putative ATP-dependent RNA helicase DHX30 isoform X2

      See identical proteins and their annotated locations for XP_006512366.1

      UniProtKB/Swiss-Prot
      Q99PU8
      Related
      ENSMUSP00000143371.1, ENSMUST00000200066.4
      Conserved Domains (5) summary
      smart00490
      Location:686785
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:438617
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:857940
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:452593
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:9801102
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    13. XM_017313615.1XP_017169104.1  putative ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8
      Conserved Domains (5) summary
      smart00490
      Location:678777
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:430609
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:849932
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:444585
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:9721094
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
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