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    TPR translocated promoter region, nuclear basket protein [ Homo sapiens (human) ]

    Gene ID: 7175, updated on 4-Nov-2018

    Summary

    Official Symbol
    TPRprovided by HGNC
    Official Full Name
    translocated promoter region, nuclear basket proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12017
    See related
    Ensembl:ENSG00000047410 MIM:189940; Vega:OTTHUMG00000035580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 29.9), thyroid (RPKM 16.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See TPR in Genome Data Viewer
    Location:
    1q31.1
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (186311652..186375325, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (186280784..186344883, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985239 Neighboring gene uncharacterized GS1-204I12.4 Neighboring gene hemicentin 1 Neighboring gene uncharacterized LOC105371654 Neighboring gene RNA, U6 small nuclear 1240, pseudogene Neighboring gene proteoglycan 4 Neighboring gene uncharacterized LOC102724919 Neighboring gene odr-4 GPCR localization factor homolog Neighboring gene oculomedin Neighboring gene phosducin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication requires PSIP1 (LEDGF/p75) and TPR to maintain chromatin structure amenable to integration as shown through shRNA treatment PubMed
    HIV-1 requires NUP153 and TPR for infectivity as shown by shRNA knockdown experiments utilizing HeLa-derived P4-CCR5 cells and jurkat T cells PubMed
    Knockdown of translocated promoter region (to activated MET oncogene) (TPR) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated nucleoprotein TPR is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat Depletion of translocated promoter region, nuclear basket protein (TPR) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem (from REACTOME)
      Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystemInfluenza genomic RNA (vRNA), synthesized in the nucleus of the infected host cell, is packaged into ribonucleoprotein (RNP) complexes containing viral polymerase proteins and NP (nucleocapsid). NP ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
      Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
    • Glucose transport, organism-specific biosystem (from REACTOME)
      Glucose transport, organism-specific biosystemCells take up glucose by facilitated diffusion, via glucose transporters (GLUTs) associated with the plasma membrane, a reversible reaction (Joost and Thorens 2001). Four tissue-specific GLUT isoform...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Hexose transport, organism-specific biosystem (from REACTOME)
      Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Host Interactions with Influenza Factors, organism-specific biosystem (from REACTOME)
      Host Interactions with Influenza Factors, organism-specific biosystemInfection of a human host cell with influenza virus triggers an array of host processes that interfere with viral replication, notably the production of type I interferon. The viral NS1 protein plays...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Influenza Viral RNA Transcription and Replication, organism-specific biosystem (from REACTOME)
      Influenza Viral RNA Transcription and Replication, organism-specific biosystemIn the host cell nucleus, the viral negative-strand RNA (vRNA) serves as a template for the synthesis both of capped, polyadenylated viral messenger RNA and of full-length positive-strand RNA or comp...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
    • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
      Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Mitotic Prophase, organism-specific biosystem (from REACTOME)
      Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
    • NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystem (from REACTOME)
      NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystemThe viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 ...
    • NS1 Mediated Effects on Host Pathways, organism-specific biosystem (from REACTOME)
      NS1 Mediated Effects on Host Pathways, organism-specific biosystemViral NS1 protein is a nuclear, dimeric protein that is highly expressed in infected cells and has dsRNA-binding activity. The RNA-binding domain lies within the N-terminal portion of the protein. Th...
    • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
      Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
    • Nuclear Pore Complex (NPC) Disassembly, organism-specific biosystem (from REACTOME)
      Nuclear Pore Complex (NPC) Disassembly, organism-specific biosystemNuclear envelope breakdown in mitosis involves permeabilization of the nuclear envelope through disassembly of the nuclear pore complex (NPC) (reviewed by Guttinger et al. 2009). Nucleoporin NUP98, l...
    • Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
      Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
    • Nuclear pore complex, organism-specific biosystem (from KEGG)
      Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Nuclear pore complex, conserved biosystem (from KEGG)
      Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystem (from REACTOME)
      Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystemGlucokinase (GCK1) is negatively regulated by glucokinase regulatory protein (GKRP), which reversibly binds the enzyme to form an inactive complex. Binding is stimulated by fructose 6-phosphate and s...
    • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
      Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...
    • Rev-mediated nuclear export of HIV RNA, organism-specific biosystem (from REACTOME)
      Rev-mediated nuclear export of HIV RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
      SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
    • SUMOylation, organism-specific biosystem (from REACTOME)
      SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
    • SUMOylation of DNA damage response and repair proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of DNA damage response and repair proteins, organism-specific biosystemSeveral factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferr...
    • SUMOylation of DNA replication proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of DNA replication proteins, organism-specific biosystemThe sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-str...
    • SUMOylation of RNA binding proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of RNA binding proteins, organism-specific biosystemSUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affini...
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Transcriptional regulation by small RNAs, organism-specific biosystem (from REACTOME)
      Transcriptional regulation by small RNAs, organism-specific biosystemRecent evidence indicates that small RNAs participate in transcriptional regulation in addition to post-transcriptional silencing. Components of the RNAi machinery (ARGONAUTE1 (AGO1, EIF2C1), AGO2 (E...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
      Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
    • Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing.
    • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
    • Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystemTransport of mature mRNAs derived from intronless transcripts require some of the same protein complexes as mRNAs derived from intron containing complexes, including TAP and Aly/Ref. However a number...
    • Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystem (from REACTOME)
      Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystemAn unusual characteristic of the influenza virus life cycle is its dependence on the nucleus. Trafficking of the viral genome into and out of the nucleus is a tightly regulated process with all viral...
    • Transport of the SLBP Dependant Mature mRNA, organism-specific biosystem (from REACTOME)
      Transport of the SLBP Dependant Mature mRNA, organism-specific biosystemTransport of U7 snRNP and stem-loop binding protein (SLBP) processed mRNA.
    • Transport of the SLBP independent Mature mRNA, organism-specific biosystem (from REACTOME)
      Transport of the SLBP independent Mature mRNA, organism-specific biosystemTransport of the SLBP independent Mature mRNA through the nuclear pore.
    • Viral Messenger RNA Synthesis, organism-specific biosystem (from REACTOME)
      Viral Messenger RNA Synthesis, organism-specific biosystemLike the mRNAs of the host cell, influenza virus mRNAs are capped and polyadenylated (reviewed in Neumann, 2004). The methylated caps, however, are scavenged from host cell mRNAs and serve as primers...
    • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
      Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
    • snRNP Assembly, organism-specific biosystem (from REACTOME)
      snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...
    • tRNA processing, organism-specific biosystem (from REACTOME)
      tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
    • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
      tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat shock protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitogen-activated protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT protein membrane anchor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural constituent of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interferon-alpha ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    mRNA export from nucleus in response to heat stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of RNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of RNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT nuclear matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT nuclear pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heterochromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to epidermal growth factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    viral process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear pore nuclear basket IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleoprotein TPR
    Names
    NPC-associated intranuclear protein
    megator
    nuclear pore complex-associated protein TPR
    translocated promoter region (to activated MET oncogene)
    translocated promoter region protein
    tumor potentiating region

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023284.1 RefSeqGene

      Range
      5001..68674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003292.2NP_003283.2  nucleoprotein TPR

      See identical proteins and their annotated locations for NP_003283.2

      Status: REVIEWED

      Source sequence(s)
      AA688415, AL133553, AL596220, U69668, X66397
      Consensus CDS
      CCDS41446.1
      UniProtKB/Swiss-Prot
      P12270
      Related
      ENSP00000356448.3, OTTHUMP00000033584, ENST00000367478.8, OTTHUMT00000086353
      Conserved Domains (5) summary
      COG1196
      Location:53796
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04527
      Location:9641050
      mycoplas_twoTM; two transmembrane protein
      pfam00038
      Location:7651087
      Filament; Intermediate filament protein
      pfam07851
      Location:14331509
      TMPIT; TMPIT-like protein
      pfam07926
      Location:10381166
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      186311652..186375325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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