Format

Send to:

Choose Destination
    • Showing Current items.

    P2ry12 purinergic receptor P2Y, G-protein coupled 12 [ Mus musculus (house mouse) ]

    Gene ID: 70839, updated on 18-Sep-2018

    Summary

    Official Symbol
    P2ry12provided by MGI
    Official Full Name
    purinergic receptor P2Y, G-protein coupled 12provided by MGI
    Primary source
    MGI:MGI:1918089
    See related
    Ensembl:ENSMUSG00000036353 Vega:OTTMUSG00000052355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2Y12; 2900079B22Rik; 4921504D23Rik
    Expression
    Broad expression in cortex adult (RPKM 10.9), frontal lobe adult (RPKM 10.2) and 15 other tissues See more
    Orthologs

    Genomic context

    See P2ry12 in Genome Data Viewer
    Location:
    3; 3 D
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (59216271..59263014, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (59020193..59066753, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12-like Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ADP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled adenosine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-mediated signaling using extracellular calcium source ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to ATP IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    glial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of integrin activation by cell surface receptor linked signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of microglial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microglial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to axon injury ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    substrate-dependent cell migration, cell extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    intrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357007.1NP_001343936.1  P2Y purinoceptor 12

      Status: VALIDATED

      Source sequence(s)
      AC122038, CN691066
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001357008.1NP_001343937.1  P2Y purinoceptor 12

      Status: VALIDATED

      Source sequence(s)
      AC122038
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001357010.1NP_001343939.1  P2Y purinoceptor 12

      Status: VALIDATED

      Source sequence(s)
      AC122038
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_027571.4NP_081847.3  P2Y purinoceptor 12

      See identical proteins and their annotated locations for NP_081847.3

      Status: VALIDATED

      Source sequence(s)
      AC122038, AK013804, AK014807, AK033448
      Consensus CDS
      CCDS17373.1
      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4
      Related
      ENSMUSP00000051353.7, OTTMUSP00000070263, ENSMUST00000050360.13
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      59216271..59263014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502085.3XP_006502148.1  P2Y purinoceptor 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4
      Related
      ENSMUSP00000143521.1, OTTMUSP00000070264, ENSMUST00000199609.1, OTTMUST00000131397
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_006502084.3XP_006502147.1  P2Y purinoceptor 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4
      Related
      ENSMUSP00000126819.1, ENSMUST00000170388.5
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_006502083.3XP_006502146.1  P2Y purinoceptor 12 isoform X1

      UniProtKB/Swiss-Prot
      Q9CPV9
      UniProtKB/TrEMBL
      Q546L4
      Related
      ENSMUSP00000143036.1, OTTMUSP00000070262, ENSMUST00000196583.4, OTTMUST00000131393
      Conserved Domains (1) summary
      cd15150
      Location:32315
      7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
    Support Center