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    Dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 69181, updated on 3-Apr-2018

    Summary

    Official Symbol
    Dyrk2provided by MGI
    Official Full Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2provided by MGI
    Primary source
    MGI:MGI:1330301
    See related
    Ensembl:ENSMUSG00000028630
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810038L18Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.4), large intestine adult (RPKM 9.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dyrk2 in Genome Data Viewer
    Location:
    10; 10 D2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (118855602..118889245, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (118296405..118305959, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33481 Neighboring gene predicted gene, 40776 Neighboring gene predicted gene, 40777 Neighboring gene predicted gene, 38403 Neighboring gene predicted gene, 33624

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 2
    Names
    dyrk2
    NP_001014412.1
    XP_006514109.1
    XP_011241854.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014390.2NP_001014412.1  dual specificity tyrosine-phosphorylation-regulated kinase 2

      See identical proteins and their annotated locations for NP_001014412.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154039
      Consensus CDS
      CCDS24201.1
      UniProtKB/Swiss-Prot
      Q5U4C9
      Related
      ENSMUSP00000004281.8, ENSMUST00000004281.9
      Conserved Domains (2) summary
      smart00220
      Location:220533
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:154533
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      118855602..118889245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243552.2XP_011241854.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_011241854.1

      Conserved Domains (2) summary
      smart00220
      Location:147460
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:81460
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
    2. XM_006514046.3XP_006514109.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:286599
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14224
      Location:220599
      PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
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