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    VAMP2 vesicle associated membrane protein 2 [ Homo sapiens (human) ]

    Gene ID: 6844, updated on 13-Jan-2020

    Summary

    Official Symbol
    VAMP2provided by HGNC
    Official Full Name
    vesicle associated membrane protein 2provided by HGNC
    Primary source
    HGNC:HGNC:12643
    See related
    Ensembl:ENSG00000220205 MIM:185881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SYB2; VAMP-2
    Summary
    The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 159.3), ovary (RPKM 45.0) and 23 other tissues See more
    Orthologs

    Genomic context

    See VAMP2 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8159147..8162948, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8062465..8066293, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Thr (anticodon AGT) 5-1 Neighboring gene period circadian regulator 1 Neighboring gene microRNA 6883 Neighboring gene uncharacterized LOC105371520 Neighboring gene transmembrane protein 107 Neighboring gene small nucleolar RNA, C/D box 118

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11460

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SNARE binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein self-association TAS
    Traceable Author Statement
    more info
    PubMed 
    syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    syntaxin-1 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    Golgi to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    eosinophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    glutamate secretion TAS
    Traceable Author Statement
    more info
     
    long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    NOT mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT natural killer cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter secretion TAS
    Traceable Author Statement
    more info
     
    NOT neutrophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    post-Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT regulation of histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SNARE complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated vesicle membrane TAS
    Traceable Author Statement
    more info
     
    clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    clathrin-sculpted glutamate transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    clathrin-sculpted monoamine transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection terminus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    secretory granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    synaptic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    synaptobrevin 2-SNAP-25-syntaxin-1a complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zymogen granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    vesicle-associated membrane protein 2
    Names
    synaptobrevin 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330125.1NP_001317054.1  vesicle-associated membrane protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC129492, BU625107
      Consensus CDS
      CCDS82064.1
      UniProtKB/TrEMBL
      F8WCA0
      Related
      ENSP00000418572.1, ENST00000488857.5
      Conserved Domains (1) summary
      cd15870
      Location:3294
      R-SNARE_VAMP2; SNARE motif of VAMP2
    2. NM_014232.3NP_055047.2  vesicle-associated membrane protein 2 isoform 1

      See identical proteins and their annotated locations for NP_055047.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC129492, AK021522, AK225777, BU625107
      Consensus CDS
      CCDS32561.1
      UniProtKB/Swiss-Prot
      P63027
      Related
      ENSP00000314214.6, ENST00000316509.11
      Conserved Domains (1) summary
      cd15870
      Location:3092
      R-SNARE_VAMP2; SNARE motif of VAMP2

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      8159147..8162948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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