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    Ppih peptidyl prolyl isomerase H [ Mus musculus (house mouse) ]

    Gene ID: 66101, updated on 18-Nov-2018

    Summary

    Official Symbol
    Ppihprovided by MGI
    Official Full Name
    peptidyl prolyl isomerase Hprovided by MGI
    Primary source
    MGI:MGI:106499
    See related
    Ensembl:ENSMUSG00000060288 Vega:OTTMUSG00000009258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CYPH; CYP-20; AI464484; D4Wsu43e; 1100001J08Rik; 2010111B15Rik; 4833408F11Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 13.0), liver E14 (RPKM 10.6) and 22 other tissues See more
    Orthologs

    Genomic context

    See Ppih in Genome Data Viewer
    Location:
    4 D2.1; 4 55.34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (119300010..119320523, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (118972615..118993128, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene 12927 Neighboring gene claudin 19 Neighboring gene Y box protein 1 Neighboring gene coiled-coil domain containing 30 Neighboring gene lactate dehydrogenase A, pseudogene 2 Neighboring gene phosphopantothenoylcysteine synthetase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    U4/U6 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase H
    Names
    PPIase H
    cyclophilin H
    rotamase H
    NP_001103599.1
    NP_001103600.1
    NP_082953.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110129.1NP_001103599.1  peptidyl-prolyl cis-trans isomerase H isoform 1

      See identical proteins and their annotated locations for NP_001103599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 3' terminal non-coding exon compared to transcript variant 1. Transcript variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK136330, AK164299, CJ071503
      Consensus CDS
      CCDS18580.1
      UniProtKB/Swiss-Prot
      Q9D868
      UniProtKB/TrEMBL
      Q3UWH9, Q4G0C5
      Related
      ENSMUSP00000101928.2, OTTMUSP00000009613, ENSMUST00000106321.8, OTTMUST00000020971
      Conserved Domains (1) summary
      cl00197
      Location:8177
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
    2. NM_001110130.1NP_001103600.1  peptidyl-prolyl cis-trans isomerase H isoform 2

      See identical proteins and their annotated locations for NP_001103600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 3' terminal exon compared to transcript variant 1, resulting in a longer isoform (2) with a different C-terminus compared to isoform 1.
      Source sequence(s)
      AK008394, BY708305, CJ071503
      Consensus CDS
      CCDS51288.1
      UniProtKB/Swiss-Prot
      Q9D868
      Related
      ENSMUSP00000101924.1, OTTMUSP00000009611, ENSMUST00000106317.1, OTTMUST00000020969
      Conserved Domains (1) summary
      cd01926
      Location:11155
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    3. NM_028677.4NP_082953.1  peptidyl-prolyl cis-trans isomerase H isoform 1

      See identical proteins and their annotated locations for NP_082953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the most predominant transcript. Transcript variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK003179, BC050116, CJ071503
      Consensus CDS
      CCDS18580.1
      UniProtKB/Swiss-Prot
      Q9D868
      UniProtKB/TrEMBL
      Q4G0C5
      Related
      ENSMUSP00000101925.1, OTTMUSP00000009612, ENSMUST00000106318.7, OTTMUST00000020970
      Conserved Domains (1) summary
      cl00197
      Location:8177
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      119300010..119320523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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