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    CFC1B cripto, FRL-1, cryptic family 1B [ Homo sapiens (human) ]

    Gene ID: 653275, updated on 2-Oct-2018

    Summary

    Official Symbol
    CFC1Bprovided by HGNC
    Official Full Name
    cripto, FRL-1, cryptic family 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:33983
    See related
    Ensembl:ENSG00000152093 Vega:OTTHUMG00000153959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in stomach (RPKM 4.2), prostate (RPKM 2.9) and 2 other tissues See more
    Orthologs

    Genomic context

    See CFC1B in Genome Data Viewer
    Location:
    2q21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (130521094..130527992)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131278667..131285565)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily F member 62, pseudogene Neighboring gene POTE ankyrin domain family member I Neighboring gene RNA, U6 small nuclear 473, pseudogene Neighboring gene serine protease 40-like Neighboring gene serine protease 40B Neighboring gene serine protease 40A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    activin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nodal binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    determination of left/right symmetry IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nodal signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079530.1NP_001072998.1  cryptic family protein 1B precursor

      See identical proteins and their annotated locations for NP_001072998.1

      Status: VALIDATED

      Source sequence(s)
      AC013269, BM716751, BQ777283, BU784123
      Consensus CDS
      CCDS33286.1
      UniProtKB/Swiss-Prot
      P0CG36
      Related
      ENSP00000281882.3, OTTHUMP00000162396, ENST00000281882.7, OTTHUMT00000254521
      Conserved Domains (2) summary
      cd00054
      Location:91115
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam09443
      Location:123157
      CFC; Cripto_Frl-1_Cryptic (CFC)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      130521094..130527992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263737.4XP_005263794.1  cryptic family protein 1B isoform X1

      See identical proteins and their annotated locations for XP_005263794.1

      UniProtKB/TrEMBL
      A0A087X0G3
      Related
      ENSP00000483368.1, ENST00000619050.4
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