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    Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56010, updated on 12-Aug-2018

    Summary

    Official Symbol
    Ywhagprovided by RGD
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gammaprovided by RGD
    Primary source
    RGD:62002
    See related
    Ensembl:ENSRNOG00000001436
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    14-3-3G
    Summary
    belongs to the 14-3-3 family of proteins; mediates signal transduction via activation of protein kinase C and calcium/calmodulin-dependent protein kinase II [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 927.4), Adrenal (RPKM 580.4) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ywhag in Genome Data Viewer
    Location:
    12q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23789547..23817884)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (25788140..25816532)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352434 Neighboring gene zona pellucida glycoprotein 3 Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene heat shock protein family B (small) member 1 Neighboring gene serine/arginine repetitive matrix 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein targeting IEA
    Inferred from Electronic Annotation
    more info
     
    protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    14-3-3 protein gamma
    Names
    14-3-3 protein gamma-subtype
    3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide
    tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma
    tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide
    tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
    tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019376.2NP_062249.1  14-3-3 protein gamma

      See identical proteins and their annotated locations for NP_062249.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127496
      UniProtKB/Swiss-Prot
      P61983
      Related
      ENSRNOP00000001954.2, ENSRNOT00000001954.3
      Conserved Domains (1) summary
      cd10024
      Location:2247
      14-3-3_gamma; 14-3-3 gamma, an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      23789547..23817884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249184.3XP_006249246.2  14-3-3 protein gamma isoform X1

      UniProtKB/Swiss-Prot
      P61983
      Related
      ENSRNOP00000069671.1, ENSRNOT00000084730.1
      Conserved Domains (1) summary
      cd10024
      Location:2247
      14-3-3_gamma; 14-3-3 gamma, an isoform of 14-3-3 protein

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      22507939..22536185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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