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    BRK1 BRICK1 subunit of SCAR/WAVE actin nucleating complex [ Homo sapiens (human) ]

    Gene ID: 55845, updated on 17-Jun-2019

    Summary

    Official Symbol
    BRK1provided by HGNC
    Official Full Name
    BRICK1 subunit of SCAR/WAVE actin nucleating complexprovided by HGNC
    Primary source
    HGNC:HGNC:23057
    See related
    Ensembl:ENSG00000254999 MIM:611183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDS027; hHBrk1; C3orf10; HSPC300
    Expression
    Ubiquitous expression in fat (RPKM 95.9), kidney (RPKM 81.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See BRK1 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (10115675..10127190)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (10157333..10168874)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 3p25 FANCD2 Alu-mediated recombination region Neighboring gene FA complementation group D2 Neighboring gene CYCS pseudogene 11 Neighboring gene FANCD2 opposite strand Neighboring gene 3p25 BRK1 Alu-mediated recombination region Neighboring gene 3p25 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Alu-mediated recombination region Neighboring gene 3p25 IRAK2 Alu-mediated recombination region Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene interleukin 1 receptor associated kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to Rac GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homotrimerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SCAR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein BRICK1
    Names
    BRICK1, SCAR/WAVE actin nucleating complex subunit
    haematopoietic stem/progenitor cell protein 300

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018462.5NP_060932.2  protein BRICK1

      See identical proteins and their annotated locations for NP_060932.2

      Status: VALIDATED

      Source sequence(s)
      AY148219
      Consensus CDS
      CCDS54553.1
      UniProtKB/Swiss-Prot
      Q8WUW1
      Related
      ENSP00000432472.1, ENST00000530758.2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      10115675..10127190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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