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    IL17RB interleukin 17 receptor B [ Homo sapiens (human) ]

    Gene ID: 55540, updated on 15-Apr-2019

    Summary

    Official Symbol
    IL17RBprovided by HGNC
    Official Full Name
    interleukin 17 receptor Bprovided by HGNC
    Primary source
    HGNC:HGNC:18015
    See related
    Ensembl:ENSG00000056736 MIM:605458
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRL4; EVI27; IL17BR; IL17RH1
    Summary
    The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 18.0), liver (RPKM 7.7) and 21 other tissues See more
    Orthologs

    Genomic context

    See IL17RB in Genome Data Viewer
    Location:
    3p21.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (53846550..53867388)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53880577..53899827)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S25 pseudogene 4 Neighboring gene calcium voltage-gated channel subunit alpha1 D Neighboring gene choline dehydrogenase Neighboring gene actin related protein 8 Neighboring gene selenoprotein K Neighboring gene uncharacterized LOC105377095

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
      IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • IL-17 signaling pathway, conserved biosystem (from KEGG)
      IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
      IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-17 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-17 signaling, organism-specific biosystemInterleukin-17 (IL17) is a family of cytokines (Kawaguchi et al. 2004, Gu et al. 2013). IL17A, the founding member of the family, member of this family, is able to induce the production of other cyt...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC5245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-17-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-13 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-5 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-17 receptor B
    Names
    IL-17 receptor B
    IL-17 receptor homolog 1
    IL-17B receptor
    IL-17RB
    IL-17Rh1
    cytokine receptor CRL4
    cytokine receptor-like 4
    interleukin 17 receptor homolog 1
    interleukin-17B receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018725.4NP_061195.2  interleukin-17 receptor B precursor

      See identical proteins and their annotated locations for NP_061195.2

      Status: REVIEWED

      Source sequence(s)
      BC000980, DA093617
      Consensus CDS
      CCDS2874.1
      UniProtKB/Swiss-Prot
      Q9NRM6
      Related
      ENSP00000288167.3, ENST00000288167.8
      Conserved Domains (3) summary
      pfam08357
      Location:332479
      SEFIR; SEFIR domain
      pfam16556
      Location:33175
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:176268
      IL17R_fnIII_D2; Interleukin 17 receptor D

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      53846550..53867388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265310.5XP_005265367.1  interleukin-17 receptor B isoform X1

      Conserved Domains (3) summary
      pfam08357
      Location:361508
      SEFIR; SEFIR domain
      pfam16556
      Location:33175
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:176297
      IL17R_fnIII_D2; Interleukin 17 receptor D
    2. XM_011533941.3XP_011532243.1  interleukin-17 receptor B isoform X7

      Conserved Domains (2) summary
      pfam16556
      Location:33175
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:176297
      IL17R_fnIII_D2; Interleukin 17 receptor D
    3. XM_017006807.2XP_016862296.1  interleukin-17 receptor B isoform X9

      Related
      ENSP00000418638.1, ENST00000494338.1
    4. XM_005265311.5XP_005265368.1  interleukin-17 receptor B isoform X2

      Conserved Domains (3) summary
      pfam08357
      Location:345492
      SEFIR; SEFIR domain
      pfam16556
      Location:33169
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:161281
      IL17R_fnIII_D2; Interleukin 17 receptor D
    5. XM_005265312.5XP_005265369.1  interleukin-17 receptor B isoform X3

      Conserved Domains (3) summary
      pfam08357
      Location:316463
      SEFIR; SEFIR domain
      pfam16556
      Location:33169
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:161252
      IL17R_fnIII_D2; Interleukin 17 receptor D
    6. XM_024453634.1XP_024309402.1  interleukin-17 receptor B isoform X8

      Conserved Domains (1) summary
      pfam16556
      Location:33175
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    7. XM_024453635.1XP_024309403.1  interleukin-17 receptor B isoform X10

      Conserved Domains (1) summary
      pfam16556
      Location:33175
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    8. XM_024453636.1XP_024309404.1  interleukin-17 receptor B isoform X11

      Conserved Domains (1) summary
      pfam16556
      Location:33175
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
    9. XM_017006804.2XP_016862293.1  interleukin-17 receptor B isoform X4

      Conserved Domains (3) summary
      pfam08357
      Location:244391
      SEFIR; SEFIR domain
      pfam16556
      Location:158
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:59180
      IL17R_fnIII_D2; Interleukin 17 receptor D
    10. XM_017006806.2XP_016862295.1  interleukin-17 receptor B isoform X6

    11. XM_017006805.2XP_016862294.1  interleukin-17 receptor B isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172234.1: Suppressed sequence

      Description
      NM_172234.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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