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    ZSCAN2 zinc finger and SCAN domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 54993, updated on 2-Oct-2018

    Summary

    Official Symbol
    ZSCAN2provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:20994
    See related
    Ensembl:ENSG00000176371 Vega:OTTHUMG00000074027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFP29; ZNF854
    Summary
    The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in adult mice, suggesting that it may play a role in regulating genes in germ cells. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 2.7), testis (RPKM 2.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZSCAN2 in Genome Data Viewer
    Location:
    15q25.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (84601018..84623718)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85144249..85166947)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene golgin A6 family-like 5, pseudogene Neighboring gene ubiquitin conjugating enzyme E2 Q2 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 933 Neighboring gene uncharacterized LOC105370947 Neighboring gene SCAN domain containing 2 pseudogene Neighboring gene egl-9 family hypoxia inducible factor 1 pseudogene 1 Neighboring gene WD repeat domain 73

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20595

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific NAS
    Non-traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger and SCAN domain-containing protein 2
    Names
    zfp-29
    zinc finger protein 29 homolog
    zinc finger protein 854

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047160.1 RefSeqGene

      Range
      5033..27731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007072.1NP_001007073.1  zinc finger and SCAN domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001007073.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has a different 3' terminal exon compared to transcript variants 1 and 2, resulting in the shortest isoform (3) with a distinct C-terminus.
      Source sequence(s)
      AW452266, AY279349, BC041620
      Consensus CDS
      CCDS32315.1
      UniProtKB/Swiss-Prot
      Q7Z7L9
      Related
      ENSP00000368663.3, OTTHUMP00000082616, ENST00000379358.7, OTTHUMT00000157109
      Conserved Domains (1) summary
      pfam02023
      Location:72134
      SCAN; SCAN domain
    2. NM_017894.5NP_060364.4  zinc finger and SCAN domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_060364.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a different 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (2) with a distinct C-terminus.
      Source sequence(s)
      AC048382, BC041620
      Consensus CDS
      CCDS32316.1
      UniProtKB/Swiss-Prot
      Q7Z7L9
      UniProtKB/TrEMBL
      A0A024RC69
      Related
      ENSP00000333895.3, OTTHUMP00000082615, ENST00000334141.7, OTTHUMT00000157108
      Conserved Domains (1) summary
      pfam02023
      Location:72134
      SCAN; SCAN domain
    3. NM_181877.3NP_870992.2  zinc finger and SCAN domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_870992.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK128624, AY262259, BC041620, BU733585, CK003500
      Consensus CDS
      CCDS10329.2
      UniProtKB/Swiss-Prot
      Q7Z7L9
      Related
      ENSP00000445451.1, OTTHUMP00000237255, ENST00000546148.5, OTTHUMT00000396958
      Conserved Domains (3) summary
      COG5048
      Location:220600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:72134
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      84601018..84623718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449975.1XP_024305743.1  zinc finger and SCAN domain-containing protein 2 isoform X1

      Related
      ENSP00000410198.2, ENST00000448803.6
      Conserved Domains (3) summary
      COG5048
      Location:220600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:72134
      SCAN; SCAN domain
    2. XM_024449978.1XP_024305746.1  zinc finger and SCAN domain-containing protein 2 isoform X5

      Conserved Domains (3) summary
      COG5048
      Location:251631
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:395415
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:70157
      SCAN; SCAN oligomerization domain
    3. XM_017022393.2XP_016877882.1  zinc finger and SCAN domain-containing protein 2 isoform X4

    4. XM_024449977.1XP_024305745.1  zinc finger and SCAN domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam02023
      Location:72134
      SCAN; SCAN domain
    5. XM_024449976.1XP_024305744.1  zinc finger and SCAN domain-containing protein 2 isoform X2

      Related
      ENSP00000351257.3, ENST00000358472.3
      Conserved Domains (2) summary
      COG5048
      Location:70450
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:214234
      ZF_C2H2; C2H2 Zn finger [structural motif]
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