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    Nfkbil1 NFKB inhibitor like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361794, updated on 21-Jul-2018

    Summary

    Official Symbol
    Nfkbil1provided by RGD
    Official Full Name
    NFKB inhibitor like 1provided by RGD
    Primary source
    RGD:1303310
    See related
    Ensembl:ENSRNOG00000000839 Vega:OTTRNOG00000001728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IkBL
    Summary
    human homolog is associated with susceptibility for rheumatoid arthritis [RGD, Feb 2006]
    Expression
    Biased expression in Adrenal (RPKM 44.5), Kidney (RPKM 39.0) and 9 other tissues See more
    Orthologs

    Genomic context

    See Nfkbil1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4823590..4839202)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (6903968..6919602)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene Sacm2l-ps3 pseudogene Neighboring gene DExD-box helicase 39B Neighboring gene ATPase H+ transporting V1 subunit G2 Neighboring gene tumor necrosis factor-like Neighboring gene lymphotoxin alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipopolysaccharide-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    NF-kappa-B inhibitor-like protein 1
    Names
    I-kappa-B-like protein
    ikappaBL
    inhibitor of kappa B-like protein
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
    putative inhibitor of Rel family transcription factors

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212509.2NP_997674.1  NF-kappa-B inhibitor-like protein 1

      See identical proteins and their annotated locations for NP_997674.1

      Status: VALIDATED

      Source sequence(s)
      BC099772, BX883046
      UniProtKB/Swiss-Prot
      Q8R2H1
      Related
      ENSRNOP00000001113.2, OTTRNOP00000001645, ENSRNOT00000001113.5, OTTRNOT00000002788
      Conserved Domains (4) summary
      cd00204
      Location:68138
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42109
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:83141
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:6495
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      4823590..4839202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256046.3XP_006256108.1  NF-kappa-B inhibitor-like protein 1 isoform X1

      Conserved Domains (4) summary
      cd00204
      Location:45115
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:1986
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:60118
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:4172
      ANK; ANK repeat [structural motif]

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      4419824..4434802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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