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    Gtf2i general transcription factor II I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 353256, updated on 3-Jan-2019

    Summary

    Official Symbol
    Gtf2iprovided by RGD
    Official Full Name
    general transcription factor II Iprovided by RGD
    Primary source
    RGD:727961
    See related
    Ensembl:ENSRNOG00000001479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtf2ird1
    Expression
    Biased expression in Kidney (RPKM 287.1), Adrenal (RPKM 284.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Gtf2i in Genome Data Viewer
    Location:
    12q12
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25410804..25487970)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (27420618..27497928)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene GTF2I repeat domain containing 1 Neighboring gene uncharacterized LOC108352437 Neighboring gene uncharacterized LOC103691302 Neighboring gene GTF2I repeat domain containing 2 Neighboring gene neutrophil cytosolic factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC94055

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transition between slow and fast fiber ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    general transcription factor II-I
    Names
    GTFII-I
    TFII-I

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001512.2NP_001001512.2  general transcription factor II-I

      See identical proteins and their annotated locations for NP_001001512.2

      Status: VALIDATED

      Source sequence(s)
      BC085815
      UniProtKB/Swiss-Prot
      Q5U2Y1
      Related
      ENSRNOP00000040835.2, ENSRNOT00000040356.5
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      25410804..25487970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769141.1XP_008767363.1  general transcription factor II-I isoform X8

      See identical proteins and their annotated locations for XP_008767363.1

      UniProtKB/TrEMBL
      A0A0G2K4T7
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    2. XM_006249170.3XP_006249232.1  general transcription factor II-I isoform X8

      See identical proteins and their annotated locations for XP_006249232.1

      UniProtKB/TrEMBL
      A0A0G2K4T7
      Related
      ENSRNOP00000073166.1, ENSRNOT00000077189.1
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    3. XM_017598367.1XP_017453856.1  general transcription factor II-I isoform X8

      UniProtKB/TrEMBL
      A0A0G2K4T7
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    4. XM_017598371.1XP_017453860.1  general transcription factor II-I isoform X12

    5. XM_017598362.1XP_017453851.1  general transcription factor II-I isoform X3

    6. XM_017598360.1XP_017453849.1  general transcription factor II-I isoform X1

      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    7. XM_017598363.1XP_017453852.1  general transcription factor II-I isoform X4

      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    8. XM_017598361.1XP_017453850.1  general transcription factor II-I isoform X2

      UniProtKB/Swiss-Prot
      Q5U2Y1
      Related
      ENSRNOP00000002020.3, ENSRNOT00000002020.6
      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    9. XM_017598365.1XP_017453854.1  general transcription factor II-I isoform X6

      Conserved Domains (1) summary
      pfam02946
      Location:112184
      GTF2I; GTF2I-like repeat
    10. XM_017598364.1XP_017453853.1  general transcription factor II-I isoform X5

    11. XM_017598368.1XP_017453857.1  general transcription factor II-I isoform X9

    12. XM_017598366.1XP_017453855.1  general transcription factor II-I isoform X7

    13. XM_017598370.1XP_017453859.1  general transcription factor II-I isoform X11

    14. XM_017598369.1XP_017453858.1  general transcription factor II-I isoform X10

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      24164158..24238521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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