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    IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) [ Homo sapiens (human) ]

    Gene ID: 3494, updated on 5-Aug-2018

    Summary

    Official Symbol
    IGHA2provided by HGNC
    Official Full Name
    immunoglobulin heavy constant alpha 2 (A2m marker)provided by HGNC
    Primary source
    HGNC:HGNC:5479
    See related
    IMGT/GENE-DB:IGHA2; MIM:147000
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

    Genomic context

    See IGHA2 in Genome Data Viewer
    Location:
    14q32.33
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (105586937..105588394, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106053274..106054731, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370698 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 1 Neighboring gene ELK2B, member of ETS oncogene family, pseudogene Neighboring gene microRNA 8071-1 Neighboring gene immunoglobulin heavy constant epsilon Neighboring gene immunoglobulin heavy locus

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • constant region of heavy chain of IgA2
    • immunoglobulin alpha 2 (A2M marker)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    antigen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to immunoglobulin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagocytosis, recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of respiratory burst IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    retina homeostasis HEP PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001019.6 

      Range
      1291951..1293438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      105586937..105588394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_1

    Genomic

    1. NT_187600.1 Reference GRCh38.p12 ALT_REF_LOCI_1

      Range
      55293..56750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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