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    NACA2 nascent polypeptide associated complex subunit alpha 2 [ Homo sapiens (human) ]

    Gene ID: 342538, updated on 5-Aug-2018

    Summary

    Official Symbol
    NACA2provided by HGNC
    Official Full Name
    nascent polypeptide associated complex subunit alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:23290
    See related
    Ensembl:ENSG00000253506 MIM:609274; Vega:OTTHUMG00000132321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANAC; NACAL
    Orthologs

    Genomic context

    See NACA2 in Genome Data Viewer
    Location:
    17q23.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (61590433..61591202, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (59667794..59668563, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 82 Neighboring gene T-box 4 Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene VISTA enhancer hs778 Neighboring gene integrator complex subunit 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
    NHGRI GWA Catalog
    Many sequence variants affecting diversity of adult human height.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nascent polypeptide-associated complex alpha subunit 2 (NACA2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC71999

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nascent polypeptide-associated complex subunit alpha-2
    Names
    IgE autoantigen alpha-nascent polypeptide-associated complex
    alpha-NAC protein
    hom s 2.01 protein
    nascent polypeptide associated complex alpha subunit 2
    nascent polypeptide-associated complex, alpha polypeptide, 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199290.3NP_954984.1  nascent polypeptide-associated complex subunit alpha-2

      See identical proteins and their annotated locations for NP_954984.1

      Status: VALIDATED

      Source sequence(s)
      BC062710
      Consensus CDS
      CCDS11630.1
      UniProtKB/Swiss-Prot
      Q9H009
      Related
      ENSP00000427802.1, OTTHUMP00000225021, ENST00000521764.2, OTTHUMT00000255437
      Conserved Domains (2) summary
      cd14415
      Location:174214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      pfam01849
      Location:82128
      NAC; NAC domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      61590433..61591202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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