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    IFNE interferon epsilon [ Homo sapiens (human) ]

    Gene ID: 338376, updated on 12-May-2019

    Summary

    Official Symbol
    IFNEprovided by HGNC
    Official Full Name
    interferon epsilonprovided by HGNC
    Primary source
    HGNC:HGNC:18163
    See related
    Ensembl:ENSG00000184995 MIM:615223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFN-E; IFNE1; IFNT1; INFE1; PRO655
    Orthologs

    Genomic context

    See IFNE in Genome Data Viewer
    Location:
    9p21.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (21480839..21482313, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21480838..21482312, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene interferon alpha 1 Neighboring gene MIR31 host gene Neighboring gene interferon omega 1 pseudogene 19 Neighboring gene microRNA 31 Neighboring gene uncharacterized LOC107987026 Neighboring gene KH-type splicing regulatory protein pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • RIG-I-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
      RIG-I-like Receptor Signaling, organism-specific biosystemViral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initia...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC119018, MGC119020

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    type I interferon receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    natural killer cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to exogenous dsRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon epsilon
    Names
    IFN-epsilon
    interferon epsilon 1
    interferon tau-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176891.4NP_795372.1  interferon epsilon precursor

      See identical proteins and their annotated locations for NP_795372.1

      Status: VALIDATED

      Source sequence(s)
      AL353732, AY358570
      Consensus CDS
      CCDS34997.1
      UniProtKB/Swiss-Prot
      Q86WN2
      Related
      ENSP00000418018.2, ENST00000448696.4
      Conserved Domains (1) summary
      pfam00143
      Location:29186
      Interferon; Interferon alpha/beta domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      21480839..21482313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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