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    Senp5 SUMO/sentrin specific peptidase 5 [ Mus musculus (house mouse) ]

    Gene ID: 320213, updated on 2-Oct-2018

    Summary

    Official Symbol
    Senp5provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 5provided by MGI
    Primary source
    MGI:MGI:2443596
    See related
    Ensembl:ENSMUSG00000022772 Vega:OTTMUSG00000025339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMT3IP3; AI851888; BB189556; 6230429P13Rik; A730063F07Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.7), CNS E11.5 (RPKM 4.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Senp5 in Genome Data Viewer
    Location:
    16; 16 B2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (31959670..32010744, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (31959756..32003373, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610012G03 gene Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene 40S ribosomal protein S18 pseudogene Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp564O1016

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-like protein-specific protease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sentrin-specific protease 5
    Names
    SUMO/Smt3-specific isopeptidase 3
    SUMO/sentrin specific protease 5
    sentrin/SUMO-specific protease SENP5
    NP_796077.2
    XP_006522301.1
    XP_006522302.1
    XP_006522303.1
    XP_006522305.1
    XP_006522306.1
    XP_011244235.1
    XP_017172524.1
    XP_017172525.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357087.1NP_001344016.1  sentrin-specific protease 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124681
      Conserved Domains (1) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. NM_001357088.1NP_001344017.1  sentrin-specific protease 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124681
      Conserved Domains (1) summary
      COG5160
      Location:567620
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    3. NM_177103.4NP_796077.2  sentrin-specific protease 5 isoform 1

      See identical proteins and their annotated locations for NP_796077.2

      Status: VALIDATED

      Source sequence(s)
      AC124681, AK028177, BC067014, BG146216
      Consensus CDS
      CCDS28111.1
      UniProtKB/Swiss-Prot
      Q6NXL6
      Related
      ENSMUSP00000156109.1, OTTMUSP00000030730, ENSMUST00000231360.1, OTTMUST00000062365
      Conserved Domains (1) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      31959670..32010744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522240.3XP_006522303.1  sentrin-specific protease 5 isoform X2

      Conserved Domains (1) summary
      cl23802
      Location:575721
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. XM_006522242.3XP_006522305.1  sentrin-specific protease 5 isoform X3

      Conserved Domains (1) summary
      cl23802
      Location:575701
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    3. XM_011245933.2XP_011244235.1  sentrin-specific protease 5 isoform X1

      See identical proteins and their annotated locations for XP_011244235.1

      UniProtKB/Swiss-Prot
      Q6NXL6
      Conserved Domains (1) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    4. XM_006522239.3XP_006522302.1  sentrin-specific protease 5 isoform X1

      See identical proteins and their annotated locations for XP_006522302.1

      UniProtKB/Swiss-Prot
      Q6NXL6
      Conserved Domains (1) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    5. XM_006522238.3XP_006522301.1  sentrin-specific protease 5 isoform X1

      UniProtKB/Swiss-Prot
      Q6NXL6
      Related
      ENSMUSP00000023457.5, ENSMUST00000023457.12
      Conserved Domains (1) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    6. XM_017317035.1XP_017172524.1  sentrin-specific protease 5 isoform X4

    7. XM_006522243.3XP_006522306.1  sentrin-specific protease 5 isoform X5

      Related
      ENSMUSP00000115257.1, OTTMUSP00000030731, ENSMUST00000129900.1, OTTMUST00000062367
      Conserved Domains (1) summary
      COG5160
      Location:567620
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    8. XM_017317036.1XP_017172525.1  sentrin-specific protease 5 isoform X6

    RNA

    1. XR_875823.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023801.1: Suppressed sequence

      Description
      NM_023801.1: This RefSeq was permanently suppressed because it is entirely UTR sequence.
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