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    Ptpn7 protein tyrosine phosphatase, non-receptor type 7 [ Mus musculus (house mouse) ]

    Gene ID: 320139, updated on 27-Jan-2018

    Summary

    Official Symbol
    Ptpn7provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 7provided by MGI
    Primary source
    MGI:MGI:2156893
    See related
    Ensembl:ENSMUSG00000031506 Vega:OTTMUSG00000049797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LPTP; HEPTP; BPTP-4; LC-PTP; C920001D21Rik
    Expression
    Biased expression in thymus adult (RPKM 47.9), spleen adult (RPKM 10.4) and 4 other tissues See more
    Orthologs

    Genomic context

    See Ptpn7 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (135131837..135145328)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (137029302..137041897)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene protein tyrosine phosphatase, receptor type, V Neighboring gene ADP-ribosylation factor-like 8A Neighboring gene G protein-coupled receptor 37-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

    General gene information

    Homology

    Clone Names

    • MGC107411

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 7
    Names
    hematopoietic protein-tyrosine phosphatase
    NP_796055.1
    XP_006529759.1
    XP_006529760.1
    XP_006529761.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356382.1NP_001343311.1  tyrosine-protein phosphatase non-receptor type 7

      Status: VALIDATED

      Source sequence(s)
      AC133097
      Conserved Domains (1) summary
      cd00047
      Location:122347
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_177081.4NP_796055.1  tyrosine-protein phosphatase non-receptor type 7

      See identical proteins and their annotated locations for NP_796055.1

      Status: VALIDATED

      Source sequence(s)
      AC133097
      Consensus CDS
      CCDS15315.1
      UniProtKB/Swiss-Prot
      Q8BUM3
      Related
      ENSMUSP00000045803.4, OTTMUSP00000068567, ENSMUST00000049449.10
      Conserved Domains (1) summary
      cd00047
      Location:122347
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      135131837..135145328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529698.3XP_006529761.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

      See identical proteins and their annotated locations for XP_006529761.1

      UniProtKB/Swiss-Prot
      Q8BUM3
      Conserved Domains (1) summary
      cd00047
      Location:122347
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_006529696.3XP_006529759.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

      See identical proteins and their annotated locations for XP_006529759.1

      UniProtKB/Swiss-Prot
      Q8BUM3
      Related
      ENSMUSP00000141133.1, OTTMUSP00000068566, ENSMUST00000187985.6, OTTMUST00000126837
      Conserved Domains (1) summary
      cd00047
      Location:122347
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. XM_006529697.3XP_006529760.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

      UniProtKB/Swiss-Prot
      Q8BUM3
      Related
      ENSMUSP00000129474.1, OTTMUSP00000068568, ENSMUST00000167080.2, OTTMUST00000126840
      Conserved Domains (1) summary
      cd00047
      Location:122347
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
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