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    RFESD Rieske Fe-S domain containing [ Homo sapiens (human) ]

    Gene ID: 317671, updated on 2-Oct-2018

    Summary

    Official Symbol
    RFESDprovided by HGNC
    Official Full Name
    Rieske Fe-S domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:29587
    See related
    Ensembl:ENSG00000175449 Vega:OTTHUMG00000121168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 3.0), bone marrow (RPKM 2.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See RFESD in Genome Data Viewer
    Location:
    5q15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (95646744..95658082)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (94982471..94992849)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267933 Neighboring gene G protein-coupled receptor 150 Neighboring gene uncharacterized LOC105379090 Neighboring gene spermatogenesis associated 9 Neighboring gene Rho related BTB domain containing 3 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Rieske domain-containing protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131065.1NP_001124537.1  Rieske domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001124537.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC035110, BC048979, BM263054, BX114571
      Consensus CDS
      CCDS47248.1
      UniProtKB/Swiss-Prot
      Q8TAC1
      Related
      ENSP00000413592.1, ENST00000458310.1
      Conserved Domains (1) summary
      cd03467
      Location:71149
      Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
    2. NM_001131066.1NP_001124538.1  Rieske domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001124538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      BC035110, BI551847, BX114571, DN914641
      Consensus CDS
      CCDS47248.1
      UniProtKB/Swiss-Prot
      Q8TAC1
      Related
      ENSP00000369341.4, OTTHUMP00000149981, ENST00000380005.8, OTTHUMT00000241655
      Conserved Domains (1) summary
      cd03467
      Location:71149
      Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
    3. NM_173362.3NP_775498.1  Rieske domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_775498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, compared to variant 1, that results in the use of an in-frame downstream start codon. The encoded protein (isoform 2) is has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC035110, BC048979, BX114571
      Consensus CDS
      CCDS4075.1
      UniProtKB/Swiss-Prot
      Q8TAC1
      UniProtKB/TrEMBL
      A0A024RAR3
      Related
      ENSP00000309229.4, OTTHUMP00000149980, ENST00000311364.8, OTTHUMT00000241654
      Conserved Domains (1) summary
      cd03467
      Location:1896
      Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      95646744..95658082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543361.2XP_011541663.1  Rieske domain-containing protein isoform X2

      See identical proteins and their annotated locations for XP_011541663.1

      UniProtKB/Swiss-Prot
      Q8TAC1
      UniProtKB/TrEMBL
      A0A024RAR3
      Conserved Domains (1) summary
      cd03467
      Location:1896
      Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
    2. XM_017009413.1XP_016864902.1  Rieske domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q8TAC1
      Conserved Domains (1) summary
      cd03467
      Location:71149
      Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
    3. XM_011543360.2XP_011541662.1  Rieske domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_011541662.1

      UniProtKB/Swiss-Prot
      Q8TAC1
      Conserved Domains (1) summary
      cd03467
      Location:71149
      Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
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