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    Dlg4 discs large MAGUK scaffold protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29495, updated on 21-May-2019

    Summary

    Official Symbol
    Dlg4provided by RGD
    Official Full Name
    discs large MAGUK scaffold protein 4provided by RGD
    Primary source
    RGD:68424
    See related
    Ensembl:ENSRNOG00000018526
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dlgh4; PSD95; Sap90
    Summary
    a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in Brain (RPKM 195.0), Adrenal (RPKM 29.1) and 7 other tissues See more
    Orthologs

    Genomic context

    See Dlg4 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56625845..56655543)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (56369703..56400662)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 2 Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene uncharacterized LOC102546779 Neighboring gene asialoglycoprotein receptor 1 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    D1 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    P2Y1 nucleotide receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acetylcholine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-1 adrenergic receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-2 adrenergic receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    immunoglobulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kinesin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neuroligin family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    scaffold protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    structural constituent of postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    AMPA glutamate receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    AMPA glutamate receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to potassium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to potassium ion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dendritic spine organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    establishment of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    locomotory exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory exploration behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    locomotory exploration behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuromuscular process controlling balance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal ion channel clustering TAS
    Traceable Author Statement
    more info
    PubMed 
    neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of excitatory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection arborization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic neurotransmitter receptor diffusion trapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic neurotransmitter receptor diffusion trapping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of NMDA receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of NMDA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of grooming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of grooming behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of grooming behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    social behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    social behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle maturation IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle maturation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vocalization behavior IEA
    Inferred from Electronic Annotation
    more info
     
    vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vocalization behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    AMPA glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    anchored component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cerebellar mossy fiber IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellar mossy fiber ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cortical cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extrinsic component of cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with ionotropic glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with ionotropic glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with ionotropic glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    juxtaparanode region of axon IEA
    Inferred from Electronic Annotation
    more info
     
    juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection terminus IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection terminus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron spine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disks large homolog 4
    Names
    PSD-95
    SAP-90
    discs, large homolog 4
    postsynaptic density protein 95
    synapse-associated protein 90
    synapse-associated protein SAP90

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019621.1NP_062567.1  disks large homolog 4

      See identical proteins and their annotated locations for NP_062567.1

      Status: PROVISIONAL

      Source sequence(s)
      M96853
      UniProtKB/Swiss-Prot
      P31016
      Related
      ENSRNOP00000059045.2, ENSRNOT00000068493.2
      Conserved Domains (7) summary
      cd12030
      Location:430495
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:544710
      GuKc; Guanylate kinase homologues
      smart00228
      Location:310394
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:65149
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:533711
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:245312
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1064
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      56625845..56655543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246684.3XP_006246746.1  disks large homolog 4 isoform X2

      Conserved Domains (8) summary
      cd12030
      Location:475540
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:589755
      GuKc; Guanylate kinase homologues
      smart00228
      Location:355439
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:110194
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:578756
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:290357
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:59109
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cl02672
      Location:3156
      L27; L27 domain
    2. XM_008767809.2XP_008766031.2  disks large homolog 4 isoform X1

      Conserved Domains (6) summary
      cd12030
      Location:370435
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:484650
      GuKc; Guanylate kinase homologues
      smart00228
      Location:250334
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:589
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:473651
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:185252
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    3. XM_006246687.3XP_006246749.1  disks large homolog 4 isoform X3

      Conserved Domains (7) summary
      cd12030
      Location:427492
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:541707
      GuKc; Guanylate kinase homologues
      smart00228
      Location:307391
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:62146
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:530708
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:242309
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1061
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    4. XM_017597176.1XP_017452665.1  disks large homolog 4 isoform X1

      Conserved Domains (6) summary
      cd12030
      Location:370435
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:484650
      GuKc; Guanylate kinase homologues
      smart00228
      Location:250334
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:589
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:473651
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:185252
      PDZ_assoc; PDZ-associated domain of NMDA receptors

    RNA

    1. XR_357666.3 RNA Sequence

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      53894685..53920691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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