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    Kpna5 karyopherin subunit alpha 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294392, updated on 21-Jul-2018

    Summary

    Official Symbol
    Kpna5provided by RGD
    Official Full Name
    karyopherin subunit alpha 5provided by RGD
    Primary source
    RGD:1561324
    See related
    Ensembl:ENSRNOG00000030109
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ipoa6
    Expression
    Biased expression in Thymus (RPKM 75.1), Spleen (RPKM 74.7) and 9 other tissues See more
    Orthologs

    Genomic context

    See Kpna5 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32509573..32573591)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (34293492..34357497)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene lysine--tRNA ligase-like Neighboring gene radial spoke head component 4A Neighboring gene zinc finger containing ubiquitin peptidase 1 Neighboring gene heat shock cognate 71 kDa protein pseudogene Neighboring gene uncharacterized LOC103694421 Neighboring gene zinc finger protein 41-like Neighboring gene G protein-coupled receptor, class C, group 6, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    importin subunit alpha-6
    Names
    karyopherin alpha 5 (importin alpha 6)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025113.1NP_001020284.1  importin subunit alpha-6

      See identical proteins and their annotated locations for NP_001020284.1

      Status: PROVISIONAL

      Source sequence(s)
      AY779029
      UniProtKB/Swiss-Prot
      Q56R16
      Related
      ENSRNOP00000039571.4, ENSRNOT00000046268.4
      Conserved Domains (5) summary
      COG5064
      Location:33525
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:251365
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:6102
      IBB; Importin beta binding domain
      pfam16186
      Location:464508
      Arm_3; Atypical Arm repeat
      sd00043
      Location:254279
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      32509573..32573591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256442.2XP_006256504.1  importin subunit alpha-6 isoform X1

      Conserved Domains (5) summary
      COG5064
      Location:36528
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:254368
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:9105
      IBB; Importin beta binding domain
      pfam16186
      Location:467511
      Arm_3; Atypical Arm repeat
      sd00043
      Location:257282
      ARM; armadillo repeat [structural motif]
    2. XM_008772879.1XP_008771101.1  importin subunit alpha-6 isoform X2

      Conserved Domains (4) summary
      cd00020
      Location:172286
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:123
      IBB; Importin beta binding domain
      pfam16186
      Location:385429
      Arm_3; Atypical Arm repeat
      sd00043
      Location:175200
      ARM; armadillo repeat [structural motif]

    RNA

    1. XR_362222.2 RNA Sequence

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      32243955..32300694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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