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    Stn1 STN1, CST complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294025, updated on 12-Aug-2018

    Summary

    Official Symbol
    Stn1provided by RGD
    Official Full Name
    STN1, CST complex subunitprovided by RGD
    Primary source
    RGD:1305637
    See related
    Ensembl:ENSRNOG00000020376
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Obfc1
    Expression
    Biased expression in Adrenal (RPKM 43.8), Lung (RPKM 41.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Stn1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267281786..267315714, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (274714582..274748515, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene SH3 and PX domains 2A Neighboring gene uncharacterized LOC102552122 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene uncharacterized LOC108349533 Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene STE20-like kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    single-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded telomeric DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere capping IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    telomere maintenance via telomere lengthening IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere maintenance via telomere lengthening IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    CST complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    CST complex IEA
    Inferred from Electronic Annotation
    more info
     
    CST complex ISO
    Inferred from Sequence Orthology
    more info
     
    fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    CST complex subunit STN1
    Names
    oligonucleotide/oligosaccharide-binding fold containing 1
    oligonucleotide/oligosaccharide-binding fold-containing protein 1
    suppressor of cdc thirteen homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011943.1NP_001011943.1  CST complex subunit STN1

      See identical proteins and their annotated locations for NP_001011943.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079096
      UniProtKB/Swiss-Prot
      Q6AYD2
      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...
      pfam09170
      Location:167374
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      267281786..267315714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589043.1XP_017444532.1  CST complex subunit STN1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHR9
      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...
      pfam09170
      Location:167343
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
    2. XM_006231472.2XP_006231534.1  CST complex subunit STN1 isoform X1

      See identical proteins and their annotated locations for XP_006231534.1

      UniProtKB/TrEMBL
      A0A0H2UHR9
      Related
      ENSRNOP00000027614.6, ENSRNOT00000027614.7
      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...
      pfam09170
      Location:167343
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
    3. XM_006231475.3XP_006231537.1  CST complex subunit STN1 isoform X3

      Conserved Domains (2) summary
      pfam09170
      Location:130306
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1
      cl09930
      Location:44128
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    4. XM_006231474.3XP_006231536.1  CST complex subunit STN1 isoform X2

      Conserved Domains (2) summary
      cd04483
      Location:65165
      hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...
      pfam09170
      Location:167342
      STN1_2; CST, Suppressor of cdc thirteen homolog, complex subunit STN1

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      242163081..242196275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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