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    Cul1 cullin 1 [ Mus musculus (house mouse) ]

    Gene ID: 26965, updated on 9-Sep-2018

    Summary

    Official Symbol
    Cul1provided by MGI
    Official Full Name
    cullin 1provided by MGI
    Primary source
    MGI:MGI:1349658
    See related
    Ensembl:ENSMUSG00000029686 Vega:OTTMUSG00000022333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cul-1
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.9), bladder adult (RPKM 24.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cul1 in Genome Data Viewer
    Location:
    6; 6 B2.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (47453737..47526139)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (47404323..47476138)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 2 Neighboring gene predicted gene, 35280 Neighboring gene predicted gene, 35565 Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene predicted gene, 40371 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IC
    Inferred by Curator
    more info
    PubMed 
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein monoubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355550.1NP_001342479.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Conserved Domains (2) summary
      smart00884
      Location:703770
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22660
      Cullin; Cullin family
    2. NM_001355551.1NP_001342480.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Conserved Domains (2) summary
      smart00884
      Location:703770
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22660
      Cullin; Cullin family
    3. NM_012042.4NP_036172.1  cullin-1

      See identical proteins and their annotated locations for NP_036172.1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Consensus CDS
      CCDS20095.1
      UniProtKB/Swiss-Prot
      Q9WTX6
      Related
      ENSMUSP00000031697.8, OTTMUSP00000025305, ENSMUST00000031697.8
      Conserved Domains (2) summary
      smart00884
      Location:703770
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22660
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      47453737..47526139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506188.3XP_006506251.1  cullin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9WTX6
      Related
      ENSMUSP00000122702.1, OTTMUSP00000025306, ENSMUST00000146200.7, OTTMUST00000053241
      Conserved Domains (2) summary
      smart00884
      Location:703770
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22660
      Cullin; Cullin family
    2. XM_006506189.3XP_006506252.1  cullin-1 isoform X1

      See identical proteins and their annotated locations for XP_006506252.1

      UniProtKB/Swiss-Prot
      Q9WTX6
      Conserved Domains (2) summary
      smart00884
      Location:703770
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22660
      Cullin; Cullin family
    3. XM_006506190.3XP_006506253.1  cullin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9WTX6
      Conserved Domains (2) summary
      smart00884
      Location:703770
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22660
      Cullin; Cullin family
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