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    Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 26876, updated on 5-Aug-2018

    Summary

    Official Symbol
    Adh4provided by MGI
    Official Full Name
    alcohol dehydrogenase 4 (class II), pi polypeptideprovided by MGI
    Primary source
    MGI:MGI:1349472
    See related
    Ensembl:ENSMUSG00000037797 Vega:OTTMUSG00000030507
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adh2
    Expression
    Biased expression in liver adult (RPKM 28.8), testis adult (RPKM 3.3) and 2 other tissues See more
    Orthologs

    Genomic context

    See Adh4 in Genome Data Viewer
    Location:
    3; 3 G3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (138415497..138430892)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (138078461..138093856)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 6B (class V) Neighboring gene alcohol dehydrogenase 6 (class V), pseudogene 1 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene methionyl aminopeptidase 1 Neighboring gene predicted gene, 32553

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    NADPH:quinone reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alcohol dehydrogenase (NAD) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alcohol dehydrogenase (NAD) activity ISO
    Inferred from Sequence Orthology
    more info
     
    alcohol dehydrogenase activity, zinc-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alcohol dehydrogenase activity, zinc-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    alditol:NADP+ 1-oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    all-trans retinal binding ISO
    Inferred from Sequence Orthology
    more info
     
    benzaldehyde dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ethanol binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    retinol binding ISO
    Inferred from Sequence Orthology
    more info
     
    retinol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    alcohol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alcohol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular aldehyde metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular aldehyde metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ethanol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ethanol oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    quinone metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alcohol dehydrogenase 4
    Names
    alcohol dehydrogenase II
    alcohol dehydrogenase class II
    class II type ADH
    NP_036126.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011996.2NP_036126.2  alcohol dehydrogenase 4

      See identical proteins and their annotated locations for NP_036126.2

      Status: PROVISIONAL

      Source sequence(s)
      AK132994
      Consensus CDS
      CCDS38653.1
      UniProtKB/Swiss-Prot
      Q9QYY9
      Related
      ENSMUSP00000013458.8, OTTMUSP00000039621, ENSMUST00000013458.8, OTTMUST00000075538
      Conserved Domains (2) summary
      cd08299
      Location:3377
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
      COG1062
      Location:8377
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      138415497..138430892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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