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    SLC13A4 solute carrier family 13 member 4 [ Homo sapiens (human) ]

    Gene ID: 26266, updated on 2-Oct-2018

    Summary

    Official Symbol
    SLC13A4provided by HGNC
    Official Full Name
    solute carrier family 13 member 4provided by HGNC
    Primary source
    HGNC:HGNC:15827
    See related
    Ensembl:ENSG00000164707 MIM:604309; Vega:OTTHUMG00000155539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAS2; SUT1; SUT-1
    Expression
    Biased expression in placenta (RPKM 28.4) and testis (RPKM 3.0) See more
    Orthologs

    Genomic context

    See SLC13A4 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (135681237..135728204, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (135365979..135412943, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 pseudogene 11 Neighboring gene RNA, U6 small nuclear 1154, pseudogene Neighboring gene short transmembrane mitochondrial protein 1 Neighboring gene uncharacterized LOC105375521 Neighboring gene uncharacterized LOC107986851 Neighboring gene family with sequence similarity 180 member A Neighboring gene uncharacterized LOC105375522

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium:dicarboxylate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium:sulfate symporter activity TAS
    Traceable Author Statement
    more info
     
    succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    succinate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sulfate transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 13 member 4
    Names
    Na(+)/sulfate cotransporter SUT-1
    solute carrier family 13 (sodium/sulfate symporter), member 4
    solute carrier family 13 (sodium/sulfate symporters), member 4
    solute carrier family 13 (sodium/sulphate symporters), member 4
    sulphate transporter 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318192.1NP_001305121.1  solute carrier family 13 member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB208809, AF169301, BC030689
      UniProtKB/Swiss-Prot
      Q9UKG4
      UniProtKB/TrEMBL
      Q59HF0
      Conserved Domains (2) summary
      cd01115
      Location:38605
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
      TIGR00785
      Location:40604
      dass; anion transporter
    2. NM_012450.3NP_036582.2  solute carrier family 13 member 4 isoform 2

      See identical proteins and their annotated locations for NP_036582.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB208809, AF169301, BC030689
      Consensus CDS
      CCDS5840.1
      UniProtKB/Swiss-Prot
      Q9UKG4
      UniProtKB/TrEMBL
      Q59HF0
      Related
      ENSP00000297282.5, OTTHUMP00000208203, ENST00000354042.8, OTTHUMT00000340558
      Conserved Domains (1) summary
      cd01115
      Location:38604
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      135681237..135728204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516024.3XP_011514326.1  solute carrier family 13 member 4 isoform X1

      See identical proteins and their annotated locations for XP_011514326.1

      Conserved Domains (1) summary
      cl21473
      Location:32570
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
    2. XM_017011962.1XP_016867451.1  solute carrier family 13 member 4 isoform X2

    3. XM_017011963.2XP_016867452.1  solute carrier family 13 member 4 isoform X3

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