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    ZNF473 zinc finger protein 473 [ Homo sapiens (human) ]

    Gene ID: 25888, updated on 17-Jun-2019

    Summary

    Official Symbol
    ZNF473provided by HGNC
    Official Full Name
    zinc finger protein 473provided by HGNC
    Primary source
    HGNC:HGNC:23239
    See related
    Ensembl:ENSG00000142528 MIM:617908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZN473; ZFP100
    Summary
    This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]
    Expression
    Broad expression in testis (RPKM 14.8), spleen (RPKM 2.3) and 21 other tissues See more
    Orthologs

    Genomic context

    See ZNF473 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (50026005..50048776)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50528786..50552033)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 16 (gene/pseudogene) Neighboring gene VRK serine/threonine kinase 3 Neighboring gene uncharacterized LOC400710 Neighboring gene zinc finger protein 420-like Neighboring gene small NF90 (ILF3) associated RNA A4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    histone mRNA metabolic process TAS
    Traceable Author Statement
    more info
     
    mRNA 3'-end processing by stem-loop binding and cleavage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    termination of RNA polymerase II transcription TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 473
    Names
    zinc finger protein 100 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051198.1 RefSeqGene

      Range
      5088..27971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001006656.4NP_001006657.1  zinc finger protein 473 isoform 1

      See identical proteins and their annotated locations for NP_001006657.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode isoform 1.
      Source sequence(s)
      AB032967, AF454744, AL080143
      Consensus CDS
      CCDS33077.1
      UniProtKB/Swiss-Prot
      Q8WTR7
      UniProtKB/TrEMBL
      A0A024QZI1
      Related
      ENSP00000375697.1, ENST00000391821.6
      Conserved Domains (3) summary
      cd07765
      Location:645
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:457860
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:732752
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001308424.3NP_001295353.1  zinc finger protein 473 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR and 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AB032967, AK302293, AL080143, BC018612, DB086543
      Consensus CDS
      CCDS77335.1
      UniProtKB/Swiss-Prot
      Q8WTR7
      UniProtKB/TrEMBL
      B4DY71, F8WEC7
      Related
      ENSP00000388961.2, ENST00000445728.7
      Conserved Domains (4) summary
      COG5048
      Location:445848
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:720740
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:732757
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:133
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    3. NM_015428.4NP_056243.1  zinc finger protein 473 isoform 1

      See identical proteins and their annotated locations for NP_056243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AB032967, AF454744, AL080143, BX492803
      Consensus CDS
      CCDS33077.1
      UniProtKB/Swiss-Prot
      Q8WTR7
      UniProtKB/TrEMBL
      A0A024QZI1
      Related
      ENSP00000270617.3, ENST00000270617.8
      Conserved Domains (3) summary
      cd07765
      Location:645
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:457860
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:732752
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      50026005..50048776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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