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    Pdgfa platelet derived growth factor subunit A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25266, updated on 18-Apr-2019

    Summary

    Official Symbol
    Pdgfaprovided by RGD
    Official Full Name
    platelet derived growth factor subunit Aprovided by RGD
    Primary source
    RGD:3282
    See related
    Ensembl:ENSRNOG00000001312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PDGFACP
    Summary
    alpha chain of platelet derived growth factor; acts as a homodimer or heterodimer with PDGF beta to activate PDGF receptors [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 73.3), Heart (RPKM 72.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Pdgfa in Genome Data Viewer
    Location:
    12q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17734141..17756186)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (19727672..19749009)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC103691050 Neighboring gene LRRGT00167 Neighboring gene 40S ribosomal protein S27-like Neighboring gene similar to Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    collagen binding IEA
    Inferred from Electronic Annotation
    more info
     
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    collagen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    growth factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet-derived growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet-derived growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet-derived growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    animal organ morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bone development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell projection assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    digestive tract development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic lung development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hair follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inner ear development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lung alveolus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of phosphatidylinositol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of platelet activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet-derived growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet-derived growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein kinase B signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT regulation of DNA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT regulation of glomerular mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of smooth muscle cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to inorganic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to wounding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    skin development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    skin development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    platelet-derived growth factor subunit A
    Names
    PDGF subunit A
    PDGF-1
    Platelet-derived growth factor A chain
    platelet derived growth factor, alpha
    platelet-derived growth factor alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012801.1NP_036933.1  platelet-derived growth factor subunit A precursor

      See identical proteins and their annotated locations for NP_036933.1

      Status: PROVISIONAL

      Source sequence(s)
      L06238
      UniProtKB/Swiss-Prot
      P28576
      Related
      ENSRNOP00000040116.4, ENSRNOT00000042117.6
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      17734141..17756186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248918.2XP_006248980.1  platelet-derived growth factor subunit A isoform X1

      See identical proteins and their annotated locations for XP_006248980.1

      UniProtKB/TrEMBL
      Q6P7C3
      Related
      ENSRNOP00000074787.1, ENSRNOT00000091476.1
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      17398134..17419591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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