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    TMED3 transmembrane p24 trafficking protein 3 [ Homo sapiens (human) ]

    Gene ID: 23423, updated on 2-Oct-2018

    Summary

    Official Symbol
    TMED3provided by HGNC
    Official Full Name
    transmembrane p24 trafficking protein 3provided by HGNC
    Primary source
    HGNC:HGNC:28889
    See related
    Ensembl:ENSG00000166557 Vega:OTTHUMG00000144170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p26; P24B; p24g4; C15orf22; p24gamma4
    Expression
    Ubiquitous expression in salivary gland (RPKM 12.9), thyroid (RPKM 6.0) and 23 other tissues See more
    Orthologs

    Genomic context

    See TMED3 in Genome Data Viewer
    Location:
    15q25.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (79311062..79413886)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (79603404..79675802)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ANKRD34C antisense RNA 1 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 3 Neighboring gene ankyrin repeat domain 34C Neighboring gene membrane integral NOTCH2 associated receptor 1 Neighboring gene uncharacterized LOC105370918 Neighboring gene uncharacterized LOC105370919

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
    • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
      COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC133022

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to ER TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    COPI vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    transport vesicle TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    transmembrane emp24 domain-containing protein 3
    Names
    integral type I protein
    membrane protein p24B
    p24 family protein gamma-4
    testis tissue sperm-binding protein Li 48e
    transmembrane emp24 protein transport domain containing 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301203.1NP_001288132.1  transmembrane emp24 domain-containing protein 3 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC027811, AI243096, AK304148, BP260160
      Consensus CDS
      CCDS73768.1
      UniProtKB/TrEMBL
      B4E277, F5H4M7
      Related
      ENSP00000446062.1, OTTHUMP00000247595, ENST00000536821.5, OTTHUMT00000416715
      Conserved Domains (1) summary
      pfam01105
      Location:28123
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    2. NM_001330376.1NP_001317305.1  transmembrane emp24 domain-containing protein 3 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a
      Source sequence(s)
      AC027811, AK297710, AL109713, BP260160
      Consensus CDS
      CCDS81914.1
      UniProtKB/Swiss-Prot
      Q9Y3Q3
      Related
      ENSP00000414983.2, ENST00000424155.6
    3. NM_001363735.1NP_001350664.1  transmembrane emp24 domain-containing protein 3 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC011797, KF459564
      Consensus CDS
      CCDS86480.1
      Conserved Domains (1) summary
      pfam01105
      Location:28130
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    4. NM_007364.3NP_031390.1  transmembrane emp24 domain-containing protein 3 isoform a precursor

      See identical proteins and their annotated locations for NP_031390.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC010853, BC022232, BM699123, BP260160
      Consensus CDS
      CCDS10310.1
      UniProtKB/Swiss-Prot
      Q9Y3Q3
      UniProtKB/TrEMBL
      A0A140VKD1
      Related
      ENSP00000299705.5, OTTHUMP00000185563, ENST00000299705.9, OTTHUMT00000291369
      Conserved Domains (1) summary
      pfam01105
      Location:28205
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    RNA

    1. NR_125394.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK075529, BC022232, BM549126, BM699123, BP260160

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      79311062..79413886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022041.1XP_016877530.1  transmembrane emp24 domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      G3V1J9
      Related
      ENSP00000440228.1, OTTHUMP00000247596, ENST00000543455.1, OTTHUMT00000416716
      Conserved Domains (1) summary
      pfam01105
      Location:28130
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
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