Format

Send to:

Choose Destination
    • Showing Current items.

    NEMP1 nuclear envelope integral membrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 23306, updated on 5-Aug-2018

    Summary

    Official Symbol
    NEMP1provided by HGNC
    Official Full Name
    nuclear envelope integral membrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:29001
    See related
    Ensembl:ENSG00000166881 MIM:616496; Vega:OTTHUMG00000171021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM194; TMEM194A
    Expression
    Ubiquitous expression in lymph node (RPKM 5.8), testis (RPKM 5.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See NEMP1 in Genome Data Viewer
    Location:
    12q13.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (57055643..57088703, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57449426..57472574, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tachykinin 3 Neighboring gene myosin IA Neighboring gene NGFI-A binding protein 2 Neighboring gene signal transducer and activator of transcription 6 Neighboring gene LDL receptor related protein 1 Neighboring gene LRP1 antisense RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0286, DKFZp686N1768

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nuclear envelope integral membrane protein 1
    Names
    transmembrane protein 194
    transmembrane protein 194A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130963.1NP_001124435.1  nuclear envelope integral membrane protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001124435.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB006624, AL833310, BQ001525, DB123768
      Consensus CDS
      CCDS44927.1
      UniProtKB/Swiss-Prot
      O14524
      Related
      ENSP00000300128.4, OTTHUMP00000244906, ENST00000300128.8, OTTHUMT00000411272
      Conserved Domains (1) summary
      pfam10225
      Location:154398
      DUF2215; Uncharacterized conserved protein (DUF2215)
    2. NM_015257.2NP_056072.2  nuclear envelope integral membrane protein 1 isoform b

      See identical proteins and their annotated locations for NP_056072.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB006624, AL833310, BC126300, BQ001525, DA724501
      Consensus CDS
      CCDS31841.1
      UniProtKB/Swiss-Prot
      O14524
      Related
      ENSP00000368701.3, OTTHUMP00000244905, ENST00000379391.7, OTTHUMT00000411271
      Conserved Domains (1) summary
      pfam10225
      Location:109325
      NEMP; NEMP family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      57055643..57088703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538056.2XP_011536358.1  nuclear envelope integral membrane protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10225
      Location:202446
      DUF2215; Uncharacterized conserved protein (DUF2215)
    2. XM_011538058.3XP_011536360.1  nuclear envelope integral membrane protein 1 isoform X3

      Conserved Domains (1) summary
      pfam10225
      Location:157373
      DUF2215; Uncharacterized conserved protein (DUF2215)
    3. XM_017019078.1XP_016874567.1  nuclear envelope integral membrane protein 1 isoform X4

      Conserved Domains (1) summary
      pfam10225
      Location:1227
      DUF2215; Uncharacterized conserved protein (DUF2215)
    4. XM_011538057.2XP_011536359.1  nuclear envelope integral membrane protein 1 isoform X2

      Conserved Domains (1) summary
      pfam10225
      Location:162406
      NEMP; NEMP family
    5. XM_024448900.1XP_024304668.1  nuclear envelope integral membrane protein 1 isoform X2

      Conserved Domains (1) summary
      pfam10225
      Location:162406
      NEMP; NEMP family
    6. XM_011538059.1XP_011536361.1  nuclear envelope integral membrane protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011536361.1

      Conserved Domains (1) summary
      pfam10225
      Location:1227
      DUF2215; Uncharacterized conserved protein (DUF2215)
    7. XM_017019079.1XP_016874568.1  nuclear envelope integral membrane protein 1 isoform X6

      Conserved Domains (1) summary
      pfam10225
      Location:1207
      DUF2215; Uncharacterized conserved protein (DUF2215)
    8. XM_011538060.2XP_011536362.1  nuclear envelope integral membrane protein 1 isoform X5

      Conserved Domains (1) summary
      pfam10225
      Location:202261
      DUF2215; Uncharacterized conserved protein (DUF2215)
    Support Center